Clusters of Orthologous Groups (COG)

• Avec la disponibilité de génomes complets, on peut s'assurer qu'une fonction est présente ou non dans une famille d'organismes.
• Les COG (Lipman et al., NCBI) sont une classification automatique des gènes trouvés dans 21 (janvier 2000) organismes séquencés (8 à l'origine).
• La classification est faite par comparaisons de tous les génomes entre eux, avec des critères raisonnables de score et de réciprocité.
• On peut observer dans chaque organisme l'absence ou, au contraire, la duplication de certains gènes.

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  COGs Functional annotation

  Code	COGs	Domains	Description	Pathways and functional systems
  Information storage and processing
  J	179	2821	Translation, ribosomal structure and biogenesis	4
  K	84	1509	Transcription	3
  L	128	1850	DNA replication, recombination and repair	1
  Cellular processes
  D	19	322	Cell division and chromosome partitioning	-
  O	75	1206	Posttranslational modification, protein turnover, chaperones	-
  M	93	1377	Cell envelope biogenesis, outer membrane	-
  N	71	892	Cell motility and secretion	-
  P	98	1457	Inorganic ion transport and metabolism	-
  T	47	1304	Signal transduction mechanisms	-
  Metabolism
  C	173	2332	Energy production and conversion	3
  G	109	1886	Carbohydrate transport and metabolism	4
  E	181	2987	Amino acid transport and metabolism	9
  F	83	1018	Nucleotide transport and metabolism	5
  H	130	1557	Coenzyme metabolism	10
  I	57	997	Lipid metabolism	1
  Poorly characterized
  R	293	4897	General function prediction only	-
  S	366	2381	Function unknown	-

  
  

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  table width=100%> 19 COGs Select Help
  

  Functional category:	D	Cell division and chromosome partitioning

  
  35 -mtk-q-c-br-ujgpolinx  [D]   COG1192 ATPases involved in chromosome partitioning
  41 amtk-qvcebr-uj--ol---  [D]   COG0455 ATPases involved in chromosome partitioning
  23 amtkyqvcebrhuj------x  [D]   COG0489 ATPases involved in chromosome partitioning, mrp family
  28 -----qvcebrhuj--olinx  [D]   COG0772 Bacterial cell division membrane protein FtsW/MrdB/SpoVE
  4 -------ce---uj-------  [D]   COG0851 Bacterial cell division topological specificity factor MinE
  7 -----qvceb--uj-------  [D]   COG0850 Bacterial septum site-determining protein MinC
  26 amtk-qvcebrhujgpol--x  [D]   COG0206 Cell division GTPase FtsZ
  4 --------ebrh---------  [D]   COG2177 Cell division protein FtsX
  18 am-kyqvc-br---gpol---  [D]   COG1196 Chromosome segregation ATPases
  22 --------ebrhuj--olinx  [D]   COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
  5 --------e-rhuj-------  [D]   COG2184 Fic protein involved in cell division
  25 a-t-yqv-eb-huj--olinx  [D]   COG1077 HSP70 class molecular chaperones involved in cell morphogenesis
  15 -m-kyqvcebrhuj-------  [D]   COG0239 Integral membrane protein possibly involved in chromosome condensation
  11 amt-y---e--h----ol--x  [D]   COG0293 Methyltranferase FtsJ involved in cell division
  4 -----qvc-b-----------  [D]   COG1206 NAD(FAD)-utilizing enzyme apparently involved in cell division
  16 ----yqvceb-hujgpolinx  [D]   COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division
  12 -----qvceb-huj--ol--x  [D]   COG0849 Predicted ATPases of the HSP70 class involved in cell division
  14 ---kyqvcebr-uj----inx  [D]   COG0424 Putative inhibitor of septum formation
  12 -------cebrhuj---l-n-  [DR]  COG1135 Uncharacterized ABC-type transport system ATPase component/cell division protein FtsE
  

  Selection
  	Function:		Text:		Species:

  
  

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  Phylogenetic patterns search

  	dc - don't care	Help
  Org dc Yes No A Afu M Mja T Mth K Pho Y Sce Q Aae V Tma	Org dc Yes No C Ssp E Eco B Bsu R Mtu H Hin U Hpy J Jhp	Org dc Yes No G Mge P Mpn O Bbu L Tpa I Ctr N Cpn X Rpr