Score E
Sequences producing significant alignments: (bits) Value
dbj|BAA77602.1| (AB019695) thioredoxin reductase II beta [H... 759 0.0
dbj|BAA77601.1| (AB019694) thioredoxin reductase II alpha [... 759 0.0
gb|AAD25167.1|AF044212_1 (AF044212) thioredoxin reductase [... 756 0.0
gb|AAD51324.1|AF171054_1 (AF171054) thioredoxin reductase T... 756 0.0
ref|NP_006431.1|PTR| thioredoxin reductase beta >gi|4378531... 756 0.0
dbj|BAA86986.1| (AB027566) thioredoxin reductase 2 [Mus mus... 672 0.0
gb|AAF03359.1|AF136399_1 (AF136399) thioredoxin reductase [... 672 0.0
gb|AAD51323.1|AF171053_1 (AF171053) thioredoxin reductase T... 672 0.0
gi|3757888 (AF072865) thioredoxin reductase [Rattus norvegi... 657 0.0
dbj|BAA82153.1| (AB022283) thioredoxin reductase [Bos taurus] 651 0.0
gi|1848294 (U88187) glutathione reductase family member [Mu... 407 e-112
dbj|BAA86985.1| (AB027565) thioredoxin reductase 1 [Mus mus... 395 e-109
sp|O62768|TRXB_BOVIN THIOREDOXIN REDUCTASE 386 e-106
gi|2997700 (AF053984) thioredoxin reductase [Bos taurus] 385 e-106
gb|AAD43039.1|AF108213_1 (AF108213) NADPH-dependent thiored... 379 e-104
gi|3582500 (U63923) thioredoxin reductase [Rattus rattus] 379 e-104
gb|AAF15900.1|AF208018_1 (AF208018) thioredoxin reductase [... 378 e-104
emb|CAA04503| (AJ001050) thioredoxin reductase [Homo sapiens] 378 e-104
dbj|BAA13674| (D88687) KM-102-derived reductase-like factor... 378 e-104
gb|AAD51325.1|AF171055_1 (AF171055) thioredoxin reductase T... 377 e-103
gi|3820535 (AF077367) thioredoxin reductase GRIM-12 [Homo s... 376 e-103
ref|NP_003321.1|PTXNRD1| thioredoxin reductase 1 >gi|250011... 375 e-103
gb|AAD39929.1|AF133519_1 (AF133519) thioredoxin reductase 3... 374 e-103
pir||S15798 glutathione reductase homolog - Caenorhabditis ... 345 6e-94
sp|P30635|GSHR_CAEEL PROBABLE GLUTATHIONE REDUCTASE (GR) (G... 345 6e-94
sp|Q17745|TRXB_CAEEL PROBABLE THIOREDOXIN REDUCTASE >gi|139... 337 2e-91
gb|AAD41826.1|AF148217_1 (AF148217) thioredoxin reductase [... 337 2e-91
gb|AAD46625.1| (AF162693) thioredoxin reductase homolog [Ca... 337 2e-91
pir||S57658 glutathione reductase - Plasmodium falciparum >... 304 1e-81
pir||S55381 glutathione reductase - Plasmodium falciparum (... 301 1e-80
emb|CAA58583| (X83603) thioredoxin reductase [Plasmodium fa... 301 1e-80
sp|P91938|GSHR_DROME GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 293 3e-78
sp|P43783|GSHR_HAEIN GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 241 1e-62
pir||S41386 glutathione reductase (NADPH) (EC 1.6.4.2) - St... 239 4e-62
sp|P47791|GSHR_MOUSE GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 235 6e-61
pdb|1DNC| Human Glutathione Reductase Modified By Digluta... 234 2e-60
pdb|1GRT| Human Glutathione Reductase A34eR37W MUTANT 234 2e-60
pdb|3GRS| Glutathione Reductase (E.C.1.6.4.2), Oxidized F... 234 2e-60
pdb|2GRT| Human Glutathione Reductase A34e, R37w Mutant, ... 234 2e-60
pdb|1XAN| Human Glutathione Reductase In Complex With A X... 234 2e-60
sp|P00390|GSHR_HUMAN GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 234 2e-60
dbj|BAA21419| (AB004537) glutathione reductase [Schizosacch... 232 5e-60
pdb|1GSN| Human Glutathione Reductase Modified By Dinitro... 230 3e-59
sp|P06715|GSHR_ECOLI GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 226 5e-58
gi|1657632 (U73174) glutathione reductase [Rattus norvegicus] 225 6e-58
gi|1778071 (U63845) glutathione reductase [Schizosaccharomy... 220 2e-56
pdb|1GES|A Escherichia coli >gi|809421|pdb|1GES|B Escherich... 218 8e-56
dbj|BAA76640.1| (AB019579) glutathione reductase (GR) [Stre... 213 4e-54
pir||S18973 glutathione reductase (NADPH) (EC 1.6.4.2) - ga... 210 2e-53
sp|P27456|GSHC_PEA GLUTATHIONE REDUCTASE, CHLOROPLAST/MITOC... 210 2e-53
gi|2425107 (AF019907) glutathione reductase (NADPH) [Vitis ... 210 3e-53
ref|NP_015234.1|GLR1| Glutathione oxidoreductase; Glr1p >gi... 208 7e-53
gi|531000 (L35342) glutathione reductase [Saccharomyces cer... 208 7e-53
emb|CAB03763.1| (Z81449) similar to pyridine nucleotide-dis... 204 1e-51
emb|CAA72516| (Y11830) glutathione reductase [Onchocerca vo... 204 2e-51
emb|CAA54043| (X76533) glutathione reductase (NADPH) [Nicot... 203 2e-51
sp|P80461|GSHC_TOBAC GLUTATHIONE REDUCTASE, CHLOROPLAST PRE... 203 3e-51
dbj|BAA07109| (D37871) glutathine reductase [Saccharomyces ... 203 3e-51
emb|CAA53993| (X76455) glutathione reductase [Nicotiana tab... 201 9e-51
emb|CAA62130| (X90528) glutathione reductase [Onchocerca vo... 201 1e-50
emb|CAA53959.2| (X76341) glutathione reductase [Mus musculus] 198 1e-49
emb|CAA06835| (AJ006055) glutathione reductase [Zea mays] 198 1e-49
sp|Q43621|GSHR_PEA GLUTATHIONE REDUCTASE, CYTOSOLIC (GR) (G... 197 2e-49
dbj|BAA36283.1| (D85751) glutathione reductase [Oryza sativ... 196 3e-49
dbj|BAA11214.1| (D78136) Glutathione Reductase [Oryza sativa] 196 3e-49
sp|P48642|GSHR_ORYSA GLUTATHIONE REDUCTASE, CYTOSOLIC (GR) ... 196 3e-49
sp|P48638|GSHR_ANASP GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 195 9e-49
sp|P48640|GSHC_SOYBN GLUTATHIONE REDUCTASE, CHLOROPLAST PRE... 194 2e-48
emb|CAA12270| (AJ224977) ORF 4 [Sphingomonas sp. RW5] 192 6e-48
sp|P42770|GSHC_ARATH GLUTATHIONE REDUCTASE, CHLOROPLAST PRE... 191 1e-47
sp|Q43154|GSHC_SPIOL GLUTATHIONE REDUCTASE, CHLOROPLAST PRE... 191 1e-47
gb|AAD28177.1|AF109694_1 (AF109694) glutathione reductase [... 190 2e-47
sp|P48641|GSHR_ARATH GLUTATHIONE REDUCTASE, CYTOSOLIC (GR) ... 187 3e-46
gi|2209384 (AF008441) glutathione reductase [Brassica rapa] 186 5e-46
sp|P23189|GSHR_PSEAE GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 185 8e-46
emb|CAA63747| (X93462) glutathione reductase [Plasmodium fa... 176 4e-43
sp|P13110|TYTR_TRYCO TRYPANOTHIONE REDUCTASE (TR) (N1,N8-BI... 176 5e-43
gi|2599403 (AF027825) glutathione reductase; PfGR3 [Plasmod... 176 5e-43
gi|2791867 (AF041450) glutathione reductase homolog [Toxopl... 173 3e-42
sp|P39051|TYTR_TRYBB TRYPANOTHIONE REDUCTASE (TR) (N1,N8-BI... 173 3e-42
pdb|2TPR|A Crithidia fasciculata >gi|443441|pdb|2TPR|B Crit... 171 1e-41
gi|162507 (M73325) trypanothione reductase [Crithidia fasci... 171 1e-41
gi|162505 (M73324) trypanothione reductase [Crithidia fasci... 171 1e-41
sp|P48639|GSHR_BURCE GLUTATHIONE REDUCTASE (GR) (GRASE) >gi... 171 1e-41
pdb|1FEA|A Chain A, Unliganded Crithidia Fasciculata Trypan... 169 4e-41
sp|P39050|TYTR_LEIDO TRYPANOTHIONE REDUCTASE (TR) (N1,N8-BI... 169 5e-41
pdb|1TYT|A Crithidia fasciculata 168 9e-41
pdb|1TYP|A Crithidia fasciculata >gi|494696|pdb|1TYP|B Crit... 168 9e-41
pdb|1TYT|B Crithidia fasciculata 168 9e-41
sp|P39040|TYTR_CRIFA TRYPANOTHIONE REDUCTASE (TR) (N1,N8-BI... 168 9e-41
pdb|1BZL|A Chain A, Crystal Structure Of Trypanosoma Cruzi ... 168 1e-40
pir||S68968 trypanothione reductase (EC 1.6.4.8) - Trypanos... 168 1e-40
pdb|1AOG|A Chain A, Trypanosoma Cruzi Trypanothione Reducta... 168 1e-40
pir||S24243 trypanothione reductase (EC 1.6.4.8) - Trypanos... 165 1e-39
sp|P28593|TYTR_TRYCR TRYPANOTHIONE REDUCTASE (TR) (N1,N8-BI... 164 1e-39
pdb|1NDA|A Trypanosoma cruzi >gi|640320|pdb|1NDA|B Trypanos... 164 1e-39
gb|AAB59211.1| (M97953) trypanothione reductase [Trypanosom... 156 4e-37
gi|552306 (M73323) trypanothione reductase [Crithidia fasci... 149 5e-35
gi|1045463 (U31954) glutathione reductase [Plasmodium falci... 147 2e-34
gi|1045461 (U31953) glutathione reductase [Plasmodium falci... 144 2e-33
dbj|BAA77602.1| (AB019695) thioredoxin reductase II beta [Homo sapiens]
Length = 494
Score = 759 bits (1939), Expect = 0.0
Identities = 370/372 (99%), Positives = 371/372 (99%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF
Sbjct: 123 KYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 182
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG
Sbjct: 183 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 242
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV
Sbjct: 243 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 302
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY
Sbjct: 303 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 362
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC
Sbjct: 363 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 422
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR
Sbjct: 423 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 482
Query: 1095 SGLDPTVTGC*G 1130
SGLDPTVTGC G
Sbjct: 483 SGLDPTVTGCXG 494
dbj|BAA77601.1| (AB019694) thioredoxin reductase II alpha [Homo sapiens]
Length = 524
Score = 759 bits (1939), Expect = 0.0
Identities = 370/372 (99%), Positives = 371/372 (99%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF
Sbjct: 153 KYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 212
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG
Sbjct: 213 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 272
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV
Sbjct: 273 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 332
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY
Sbjct: 333 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 392
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC
Sbjct: 393 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 452
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 512
Query: 1095 SGLDPTVTGC*G 1130
SGLDPTVTGC G
Sbjct: 513 SGLDPTVTGCXG 524
gb|AAD25167.1|AF044212_1 (AF044212) thioredoxin reductase [Homo sapiens]
Length = 521
Score = 756 bits (1931), Expect = 0.0
Identities = 368/370 (99%), Positives = 369/370 (99%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF
Sbjct: 150 KYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 209
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG
Sbjct: 210 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 269
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV
Sbjct: 270 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 329
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTP AIMAGRLLVQRLFGGSSDLMDY
Sbjct: 330 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDY 389
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC
Sbjct: 390 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 449
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR
Sbjct: 450 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 509
Query: 1095 SGLDPTVTGC 1124
SGLDPTVTGC
Sbjct: 510 SGLDPTVTGC 519
gb|AAD51324.1|AF171054_1 (AF171054) thioredoxin reductase TR3 [Homo sapiens]
Length = 524
Score = 756 bits (1931), Expect = 0.0
Identities = 368/370 (99%), Positives = 369/370 (99%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF
Sbjct: 153 KYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 212
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG
Sbjct: 213 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 272
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV
Sbjct: 273 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 332
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTP AIMAGRLLVQRLFGGSSDLMDY
Sbjct: 333 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDY 392
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC
Sbjct: 393 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 452
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 512
Query: 1095 SGLDPTVTGC 1124
SGLDPTVTGC
Sbjct: 513 SGLDPTVTGC 522
ref|NP_006431.1|PTR| thioredoxin reductase beta >gi|4378531|gb|AAD19597| (AF106697)
thioredoxin reductase [Homo sapiens]
Length = 524
Score = 756 bits (1931), Expect = 0.0
Identities = 368/370 (99%), Positives = 369/370 (99%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF
Sbjct: 153 KYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 212
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG
Sbjct: 213 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 272
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV
Sbjct: 273 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 332
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTP AIMAGRLLVQRLFGGSSDLMDY
Sbjct: 333 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDY 392
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC
Sbjct: 393 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 452
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 512
Query: 1095 SGLDPTVTGC 1124
SGLDPTVTGC
Sbjct: 513 SGLDPTVTGC 522
dbj|BAA86986.1| (AB027566) thioredoxin reductase 2 [Mus musculus]
Length = 520
Score = 672 bits (1716), Expect = 0.0
Identities = 320/372 (86%), Positives = 346/372 (92%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTV GV KGGK LLSA+HI+IATGGRPRYPT ++GALEYGITSDDIF
Sbjct: 149 KYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 208
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTT+MMRSIPLRGFDQQMSS+V EHM SHG
Sbjct: 209 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG 268
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
T+FL+GC PS +++LP QLQVTWED +GKEDTGTFDTVLWAIGRVP+TR+LNLEKAG+
Sbjct: 269 TQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGI 328
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
T+P QKI+VD++EATSVPHIYAIGDV EGRPELTPTAI AG+LL QRLFG SS LMDY
Sbjct: 329 STNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDY 388
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
NVPTTVFTPLEYGCVGLSEEEAVA HGQEHVEVYHA+YKPLEFTVA RDASQCY+KMVC
Sbjct: 389 SNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVC 448
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
+REPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVM+TVGIHPTCSEEVVKL ISKR
Sbjct: 449 MREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKR 508
Query: 1095 SGLDPTVTGC*G 1130
SGL+PTVTGC G
Sbjct: 509 SGLEPTVTGCXG 520
gb|AAF03359.1|AF136399_1 (AF136399) thioredoxin reductase [Mus musculus]
Length = 528
Score = 672 bits (1714), Expect = 0.0
Identities = 319/370 (86%), Positives = 345/370 (93%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTV GV KGGK LLSA+HI+IATGGRPRYPT ++GALEYGITSDDIF
Sbjct: 157 KYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 216
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTT+MMRSIPLRGFDQQMSS+V EHM SHG
Sbjct: 217 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG 276
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
T+FL+GC PS +++LP QLQVTWED +GKEDTGTFDTVLWAIGRVP+TR+LNLEKAG+
Sbjct: 277 TQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGI 336
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
T+P QKI+VD++EATSVPHIYAIGDV EGRPELTPTAI AG+LL QRLFG SS LMDY
Sbjct: 337 STNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDY 396
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
NVPTTVFTPLEYGCVGLSEEEAVA HGQEHVEVYHA+YKPLEFTVA RDASQCY+KMVC
Sbjct: 397 SNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVC 456
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
+REPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVM+TVGIHPTCSEEVVKL ISKR
Sbjct: 457 MREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKR 516
Query: 1095 SGLDPTVTGC 1124
SGL+PTVTGC
Sbjct: 517 SGLEPTVTGC 526
gb|AAD51323.1|AF171053_1 (AF171053) thioredoxin reductase TR3 [Mus musculus]
Length = 524
Score = 672 bits (1714), Expect = 0.0
Identities = 319/370 (86%), Positives = 345/370 (93%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFVDEHTV GV KGGK LLSA+HI+IATGGRPRYPT ++GALEYGITSDDIF
Sbjct: 153 KYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 212
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTT+MMRSIPLRGFDQQMSS+V EHM SHG
Sbjct: 213 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG 272
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
T+FL+GC PS +++LP QLQVTWED +GKEDTGTFDTVLWAIGRVP+TR+LNLEKAG+
Sbjct: 273 TQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGI 332
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
T+P QKI+VD++EATSVPHIYAIGDV EGRPELTPTAI AG+LL QRLFG SS LMDY
Sbjct: 333 STNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDY 392
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
NVPTTVFTPLEYGCVGLSEEEAVA HGQEHVEVYHA+YKPLEFTVA RDASQCY+KMVC
Sbjct: 393 SNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVC 452
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
+REPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVM+TVGIHPTCSEEVVKL ISKR
Sbjct: 453 MREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKR 512
Query: 1095 SGLDPTVTGC 1124
SGL+PTVTGC
Sbjct: 513 SGLEPTVTGC 522
gi|3757888 (AF072865) thioredoxin reductase [Rattus norvegicus]
Length = 526
Score = 657 bits (1676), Expect = 0.0
Identities = 312/370 (84%), Positives = 342/370 (92%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFNIKASFV+EHTV GV K GK LSA HI+IATGGRP+YPT ++GALE+GITSDDIF
Sbjct: 155 KYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIF 214
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAGFLTGIGLDTT+MMRS+PLRGFDQQM+S+V EHM SHG
Sbjct: 215 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHG 274
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TRFL+GC PS +R+LP QLQVTWED +GKED GTFDTVLWAIGRVP+TR+LNLEKAGV
Sbjct: 275 TRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGV 334
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
+T+P QKI+VD++EATSVPHIYAIGDV EGRPELTPTAI AG+LL QRLFG SS LM+Y
Sbjct: 335 NTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNY 394
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
NVPTTVFTPLEYGCVGLSEEEAVA HGQEH+EVYHA+YKPLEFTVA RDASQCY+KMVC
Sbjct: 395 SNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVC 454
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
+REPPQLVLGLHFLGPNAGEVTQGFALGI+CGASYAQVM+TVGIHPTCSEEVVKL ISKR
Sbjct: 455 MREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKR 514
Query: 1095 SGLDPTVTGC 1124
SGLDPTVTGC
Sbjct: 515 SGLDPTVTGC 524
dbj|BAA82153.1| (AB022283) thioredoxin reductase [Bos taurus]
Length = 511
Score = 651 bits (1662), Expect = 0.0
Identities = 309/370 (83%), Positives = 338/370 (90%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
+YFN+KASFVD HTVCGV+KGG+E LLSA+HI+IATGGRPRYPTHIEGALEYGITSDD+F
Sbjct: 140 KYFNVKASFVDTHTVCGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLF 199
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
WLKESPGKTLVVGASYVALECAG LTG+GLDTT+M+RS+PLR FDQQM+S+V EHMA HG
Sbjct: 200 WLKESPGKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHMAGHG 259
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
TR LRGCAP +V +LP QL+VTW D T+ ++D GTFDTVLWAIGRVP+T SLNLEKAGV
Sbjct: 260 TRILRGCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKAGV 319
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
T+P T KILVD++E TSVPHIYAIGDV EGRPELTPTAIMAGRLL QRL G +SDLMDY
Sbjct: 320 HTNPVTGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLMDY 379
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
+VPTTVFTPLEYGCVGLSEE AVARHG+EHVEVYHA YKPLEFTV RDASQCY+KMVC
Sbjct: 380 SSVPTTVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRDASQCYIKMVC 439
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
LREPPQLVLGLHFLGPNAGEV QGFALGIKCGASY Q+MRTVGIHPTC+EEV KLRISKR
Sbjct: 440 LREPPQLVLGLHFLGPNAGEVIQGFALGIKCGASYQQLMRTVGIHPTCAEEVAKLRISKR 499
Query: 1095 SGLDPTVTGC 1124
SGLDPTVTGC
Sbjct: 500 SGLDPTVTGC 509
gi|1848294 (U88187) glutathione reductase family member [Musca domestica]
Length = 495
Score = 407 bits (1035), Expect = e-112
Identities = 201/370 (54%), Positives = 255/370 (68%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
EY N SF D HTV K G E L+ +++IA GGRPRYP I GA+EYGITSDD+F
Sbjct: 127 EYINGAGSFKDPHTVVAKMKNGSERTLTGRNVVIAVGGRPRYPD-IPGAVEYGITSDDLF 185
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
L + PGKTLVVGA Y+ LECAGFL G+G D T+M+RSI LRGFDQQM++MV + M G
Sbjct: 186 SLDKEPGKTLVVGAGYIGLECAGFLKGLGYDATVMVRSIVLRGFDQQMANMVADSMVERG 245
Query: 375 TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGV 554
FL P V + DG+L V + ++ T +E + +DTVLWAIGR LNL AG+
Sbjct: 246 IPFLHKTIPKSVEKTQDGRLLVKYVNTETQEEGSDVYDTVLWAIGRKGLVDDLNLGAAGI 305
Query: 555 DTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDY 734
+ D KI V+ E T+VPHI+A+GD++ GRPELTP AI AGRLL +RLFGGS +MDY
Sbjct: 306 EVKAD--KIAVNEAEQTNVPHIFAVGDIIHGRPELTPVAIHAGRLLARRLFGGSKQIMDY 363
Query: 735 DNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVC 914
+V TTVF+PLEY CVG++EE+A+ + G++++EV+H YKP EF + + CYVK V
Sbjct: 364 TDVATTVFSPLEYACVGMAEEDAIQKFGEDNIEVFHGFYKPTEFFIPQKSVRYCYVKAVA 423
Query: 915 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
R Q VLGLH+LGP AGEV QGFA +K G + ++ TVGIHPT +EE +L I+KR
Sbjct: 424 ERSGDQKVLGLHYLGPVAGEVIQGFAAAVKSGLTMKILLNTVGIHPTTAEEFTRLAITKR 483
Query: 1095 SGLDPTVTGC 1124
SGLDPT C
Sbjct: 484 SGLDPTPASC 493
dbj|BAA86985.1| (AB027565) thioredoxin reductase 1 [Mus musculus]
Length = 499
Score = 395 bits (1004), Expect = e-109
Identities = 200/371 (53%), Positives = 260/371 (69%), Gaps = 3/371 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P+++ ++ G+L+VT + + + + G F+TVL A+GR TR++ LE
Sbjct: 246 KFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++EG+ ELTP AI AGRLL QRL+GGS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DYDNVPTTVFTPLEYGC GLSEE+AV + G+E++EVYH+ + PLE+TV RD ++CY K+
Sbjct: 366 DYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKI 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVT 485
Query: 1089 KRSGLDPTVTGC*G 1130
KRSG D +GC G
Sbjct: 486 KRSGGDILQSGCXG 499
sp|O62768|TRXB_BOVIN THIOREDOXIN REDUCTASE
Length = 499
Score = 386 bits (980), Expect = e-106
Identities = 200/371 (53%), Positives = 257/371 (68%), Gaps = 3/371 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N FV H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMQEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TVL AIGR TR + LE
Sbjct: 246 KFIRQFVPIKVEQIEAGTPGRLRVIAKSTDSDQTIEGEYNTVLLAIGRDACTRKIGLENV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++EG+ ELTP AI AGRLL QRL+GGS+
Sbjct: 306 GVKINEKTGKIPVTEEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E+VEVYH+++ PLE+T+ RD ++CY K+
Sbjct: 366 DYENVPTTVFTPLEYGSCGLSEEKAVEKFGEENVEVYHSYFWPLEWTIPSRDNNKCYAKV 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
VC + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 VCNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFTTLSVT 485
Query: 1089 KRSGLDPTVTGC*G 1130
KRSG + TGC G
Sbjct: 486 KRSGGNILQTGCCG 499
gi|2997700 (AF053984) thioredoxin reductase [Bos taurus]
Length = 499
Score = 385 bits (978), Expect = e-106
Identities = 199/369 (53%), Positives = 256/369 (68%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N FV H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMQEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TVL AIGR TR + LE
Sbjct: 246 KFIRQFVPIKVEQIEAGTPGRLRVIAKSTDSDQTIEGEYNTVLLAIGRDACTRKIGLENV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++EG+ ELTP AI AGRLL QRL+GGS+
Sbjct: 306 GVKINEKTGKIPVTEEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E+VEVYH+++ PLE+T+ RD ++CY K+
Sbjct: 366 DYENVPTTVFTPLEYGSCGLSEEKAVEKFGEENVEVYHSYFWPLEWTIPSRDNNKCYAKV 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
VC + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 VCNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFTTLSVT 485
Query: 1089 KRSGLDPTVTGC 1124
KRSG + TGC
Sbjct: 486 KRSGGNILQTGC 497
gb|AAD43039.1|AF108213_1 (AF108213) NADPH-dependent thioredoxin reductase [Rattus norvegicus]
Length = 496
Score = 379 bits (963), Expect = e-104
Identities = 195/369 (52%), Positives = 255/369 (68%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P+++ ++ G+L+VT + + + + F+TVL A+GR TR++ LE
Sbjct: 246 KFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++EG+ ELTP AI AGRLL QRL+GGS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DYDNVPTTVFTPLEYGC GLSEE+AV + G+E++EVYH+ + PLE+TV RD ++CY K+
Sbjct: 366 DYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKV 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQ +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNLKDNERVVGFHVLGPNAGEVTQALQ-PLKCGLTKQQLDSTIGIHPVCAEIFTTLSVT 484
Query: 1089 KRSGLDPTVTGC 1124
KRSG D +GC
Sbjct: 485 KRSGGDILQSGC 496
gi|3582500 (U63923) thioredoxin reductase [Rattus rattus]
Length = 498
Score = 379 bits (963), Expect = e-104
Identities = 195/369 (52%), Positives = 255/369 (68%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P+++ ++ G+L+VT + + + + F+TVL A+GR TR++ LE
Sbjct: 246 KFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++EG+ ELTP AI AGRLL QRL+GGS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DYDNVPTTVFTPLEYGC GLSEE+AV + G+E++EVYH+ + PLE+TV RD ++CY K+
Sbjct: 366 DYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKV 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQ +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNLKDNERVVGFHVLGPNAGEVTQALQ-PLKCGLTKQQLDSTIGIHPVCAEIFTTLSVT 484
Query: 1089 KRSGLDPTVTGC 1124
KRSG D +GC
Sbjct: 485 KRSGGDILQSGC 496
gb|AAF15900.1|AF208018_1 (AF208018) thioredoxin reductase [Homo sapiens]
Length = 497
Score = 378 bits (961), Expect = e-104
Identities = 192/369 (52%), Positives = 252/369 (68%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TV+ AIGR TR + LE
Sbjct: 246 KFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++E + ELTP AI AGRLL QRL+ GS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E++EVYH+++ PLE+T+ RD ++CY K+
Sbjct: 366 DYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 485
Query: 1089 KRSGLDPTVTGC 1124
KRSG GC
Sbjct: 486 KRSGASILQAGC 497
emb|CAA04503| (AJ001050) thioredoxin reductase [Homo sapiens]
Length = 497
Score = 378 bits (961), Expect = e-104
Identities = 192/369 (52%), Positives = 252/369 (68%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TV+ AIGR TR + LE
Sbjct: 246 KFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++E + ELTP AI AGRLL QRL+ GS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E++EVYH+++ PLE+T+ RD ++CY K+
Sbjct: 366 DYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 485
Query: 1089 KRSGLDPTVTGC 1124
KRSG GC
Sbjct: 486 KRSGASILQAGC 497
dbj|BAA13674| (D88687) KM-102-derived reductase-like factor [Homo sapiens]
Length = 549
Score = 378 bits (961), Expect = e-104
Identities = 192/369 (52%), Positives = 252/369 (68%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 179 YENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 237
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGLD T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 238 LPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGI 297
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TV+ AIGR TR + LE
Sbjct: 298 KFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETV 357
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++E + ELTP AI AGRLL QRL+ GS+
Sbjct: 358 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKC 417
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E++EVYH+++ PLE+T+ RD ++CY K+
Sbjct: 418 DYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI 477
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 478 ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 537
Query: 1089 KRSGLDPTVTGC 1124
KRSG GC
Sbjct: 538 KRSGASILQAGC 549
gb|AAD51325.1|AF171055_1 (AF171055) thioredoxin reductase TR2 [Homo sapiens]
Length = 579
Score = 377 bits (957), Expect = e-103
Identities = 195/369 (52%), Positives = 251/369 (67%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N FV+ H + K G+E +A +IATG RPRY I+G EY ITSDD+F
Sbjct: 207 YVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRY-LGIQGDKEYCITSDDLFS 265
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL G GLD T+M+RSI LRGFDQ+M+ V +M HG
Sbjct: 266 LPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGV 325
Query: 378 RFLRGCAPSRVRRLPDG---QLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+FLR P V++L G +L+V + + + G ++TVL AIGR TR + LEK
Sbjct: 326 KFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKI 385
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + + KI V+ E T+VP++YA+GD++E +PELTP AI +G+LL QRLFG S +
Sbjct: 386 GVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKC 445
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY NVPTTVFTPLEYGC GLSEE+A+ + +E++E+YH + PLE+TVAGR+ + CY K+
Sbjct: 446 DYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKI 505
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + V+G H LGPNAGEVTQGFA +KCG + + T+GIHPTC E L I+
Sbjct: 506 ICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEIT 565
Query: 1089 KRSGLDPTVTGC 1124
K SGLD T GC
Sbjct: 566 KSSGLDITQKGC 577
gi|3820535 (AF077367) thioredoxin reductase GRIM-12 [Homo sapiens]
Length = 497
Score = 376 bits (954), Expect = e-103
Identities = 191/369 (51%), Positives = 252/369 (67%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGL+ T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLNVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TV+ AIGR TR + LE
Sbjct: 246 KFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++E + ELTP AI AGRLL QRL+ GS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E++EVYH+++ PLE+T+ RD ++CY K+
Sbjct: 366 DYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 485
Query: 1089 KRSGLDPTVTGC 1124
KRSG GC
Sbjct: 486 KRSGARILQAGC 497
ref|NP_003321.1|PTXNRD1| thioredoxin reductase 1 >gi|2500118|sp|Q16881|TRXB_HUMAN THIOREDOXIN
REDUCTASE >gi|2136270|pir||S66677 thioredoxin reductase -
human >gi|1184537|bbs|172316 (S79851) thioredoxin
reductase {EC 1.6.4.5} [human, placenta, Peptide, 497 aa]
[Homo sapiens] >gi|1237038|emb|CAA62629| (X91247)
thioredoxin reductase (NADPH) [Homo sapiens]
Length = 497
Score = 375 bits (953), Expect = e-103
Identities = 191/369 (51%), Positives = 251/369 (67%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F+ H + GKE + SA+ +IATG RPRY I G EY I+SDD+F
Sbjct: 127 YENAYGQFIGPHRIKATNNKGKEKIYSAESFLIATGERPRY-LGIPGDKEYCISSDDLFS 185
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGKTLVVGASYVALECAGFL GIGL T+M+RSI LRGFDQ M++ + EHM HG
Sbjct: 186 LPYCPGKTLVVGASYVALECAGFLAGIGLGVTVMVRSILLRGFDQDMANKIGEHMEEHGI 245
Query: 378 RFLRGCAPSRVRRLP---DGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+F+R P +V ++ G+L+V + + + + G ++TV+ AIGR TR + LE
Sbjct: 246 KFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETV 305
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + T KI V E T+VP+IYAIGD++E + ELTP AI AGRLL QRL+ GS+
Sbjct: 306 GVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKC 365
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY+NVPTTVFTPLEYG GLSEE+AV + G+E++EVYH+++ PLE+T+ RD ++CY K+
Sbjct: 366 DYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + + V+G H LGPNAGEVTQGFA +KCG + Q+ T+GIHP C+E L ++
Sbjct: 426 ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 485
Query: 1089 KRSGLDPTVTGC 1124
KRSG GC
Sbjct: 486 KRSGASILQAGC 497
gb|AAD39929.1|AF133519_1 (AF133519) thioredoxin reductase 3 [Homo sapiens]
Length = 577
Score = 374 bits (951), Expect = e-103
Identities = 194/369 (52%), Positives = 250/369 (67%), Gaps = 3/369 (0%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N FV+ H + K G+E +A +IATG RPRY I+G EY ITSDD+F
Sbjct: 205 YVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRY-LGIQGDKEYCITSDDLFS 263
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L PGK LVVGASYVALECAGFL G GLD T+M+RSI LRGFDQ+M+ V +M HG
Sbjct: 264 LPYCPGKPLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGV 323
Query: 378 RFLRGCAPSRVRRLPDG---QLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
+FLR P V++L G +L+V + + + G ++TVL AIGR TR + LEK
Sbjct: 324 KFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKI 383
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
GV + + KI V+ E T+VP++YA+GD++E +PELTP AI +G+LL QRLFG S +
Sbjct: 384 GVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKC 443
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKM 908
DY NVPTTVFTPLEYGC GLSEE+A+ + +E++E+YH + PLE+TVAGR+ + CY K+
Sbjct: 444 DYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKI 503
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
+C + V+G H LGPNAGEVTQGFA +KCG + + T+GIHPTC E L I+
Sbjct: 504 ICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEIT 563
Query: 1089 KRSGLDPTVTGC 1124
K SGLD T GC
Sbjct: 564 KSSGLDITQKGC 575
pir||S15798 glutathione reductase homolog - Caenorhabditis elegans
Length = 499
Score = 345 bits (875), Expect = 6e-94
Identities = 178/371 (47%), Positives = 242/371 (64%), Gaps = 3/371 (0%)
Frame = +3
Query: 18 YFNIKASFVDEH--TVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 191
YFN A FVD+ + G K + LSA +++I+TG RP+YP +I GA E GITSDD+
Sbjct: 133 YFNAYAEFVDKDKIVITGTDKNKTKNFLSAPNVVISTGLRPKYP-NIPGA-ELGITSDDL 190
Query: 192 FWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASH 371
F L PGKTL+VG YVALECAGFL+ + +++RSIPL+GFD+ V+EH+ +
Sbjct: 191 FTLASVPGKTLIVGGGYVALECAGFLSAFNQNVEVLVRSIPLKGFDRDCVHFVMEHLKTT 250
Query: 372 GTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAG 551
G + RV + + +VT+ TG +DTV+WA GRVP+ +SLNL+ AG
Sbjct: 251 GVKVKEHVEVERVEAV-GSKKKVTF----TGNGGVEEYDTVIWAAGRVPNLKSLNLDNAG 305
Query: 552 VDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMD 731
V T + KIL D + S +YA+GD+V+ R ELTP AI +G+LL RLF S ++
Sbjct: 306 VRTDKRSGKILADEFDRASCNGVYAVGDIVQDRQELTPLAIQSGKLLADRLFSNSKQIVR 365
Query: 732 YDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTV-AGRDASQCYVKM 908
+D V TTVFTPLE VGL+EEEA+ +HG++ +EV+H+H+ P E+ V +D+ CYVK
Sbjct: 366 FDGVATTVFTPLELSTVGLTEEEAIQKHGEDSIEVFHSHFTPFEYVVPQNKDSGFCYVKA 425
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
VC R+ Q +LGLHF+GPNA EV QG+A+ + G S + + T+ IHP SEE VKL I+
Sbjct: 426 VCTRDESQKILGLHFVGPNAAEVIQGYAVAFRVGISMSDLQNTIAIHPCSSEEFVKLHIT 485
Query: 1089 KRSGLDPTVTGC*G 1130
KRSG DP GC G
Sbjct: 486 KRSGQDPRTQGCCG 499
sp|P30635|GSHR_CAEEL PROBABLE GLUTATHIONE REDUCTASE (GR) (GRASE)
>gi|3881674|emb|CAA77459.1| (Z11115) predicted using
Genefinder; similar to glutathione reductase; cDNA EST
EMBL:C09100 comes from this gene; cDNA EST EMBL:C07682
comes from this gene [Caenorhabditis elegans]
Length = 503
Score = 345 bits (875), Expect = 6e-94
Identities = 178/371 (47%), Positives = 242/371 (64%), Gaps = 3/371 (0%)
Frame = +3
Query: 18 YFNIKASFVDEH--TVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 191
YFN A FVD+ + G K + LSA +++I+TG RP+YP +I GA E GITSDD+
Sbjct: 137 YFNAYAEFVDKDKIVITGTDKNKTKNFLSAPNVVISTGLRPKYP-NIPGA-ELGITSDDL 194
Query: 192 FWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASH 371
F L PGKTL+VG YVALECAGFL+ + +++RSIPL+GFD+ V+EH+ +
Sbjct: 195 FTLASVPGKTLIVGGGYVALECAGFLSAFNQNVEVLVRSIPLKGFDRDCVHFVMEHLKTT 254
Query: 372 GTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAG 551
G + RV + + +VT+ TG +DTV+WA GRVP+ +SLNL+ AG
Sbjct: 255 GVKVKEHVEVERVEAV-GSKKKVTF----TGNGGVEEYDTVIWAAGRVPNLKSLNLDNAG 309
Query: 552 VDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMD 731
V T + KIL D + S +YA+GD+V+ R ELTP AI +G+LL RLF S ++
Sbjct: 310 VRTDKRSGKILADEFDRASCNGVYAVGDIVQDRQELTPLAIQSGKLLADRLFSNSKQIVR 369
Query: 732 YDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTV-AGRDASQCYVKM 908
+D V TTVFTPLE VGL+EEEA+ +HG++ +EV+H+H+ P E+ V +D+ CYVK
Sbjct: 370 FDGVATTVFTPLELSTVGLTEEEAIQKHGEDSIEVFHSHFTPFEYVVPQNKDSGFCYVKA 429
Query: 909 VCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRIS 1088
VC R+ Q +LGLHF+GPNA EV QG+A+ + G S + + T+ IHP SEE VKL I+
Sbjct: 430 VCTRDESQKILGLHFVGPNAAEVIQGYAVAFRVGISMSDLQNTIAIHPCSSEEFVKLHIT 489
Query: 1089 KRSGLDPTVTGC*G 1130
KRSG DP GC G
Sbjct: 490 KRSGQDPRTQGCCG 503
sp|Q17745|TRXB_CAEEL PROBABLE THIOREDOXIN REDUCTASE >gi|1397273 (U61947) Similar to
pyridine nucleotide-disulphide oxidoreductase.
[Caenorhabditis elegans]
Length = 523
Score = 337 bits (854), Expect = 2e-91
Identities = 172/361 (47%), Positives = 245/361 (67%), Gaps = 11/361 (3%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F + K K L+AD +I+TG RP+YP I G EY ITSDD+F
Sbjct: 146 YINSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYP-EIPGVKEYTITSDDLFQ 204
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L SPGKTL VGASYV+LECAGFL G G D T+M+RSI LRGFDQ M+ + +HM ++G
Sbjct: 205 LPYSPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHMIAYGM 264
Query: 378 RFLRGCAPSRVRRLPD------GQLQVTW----EDSTTGKEDTGTFDTVLWAIGRVPDTR 527
+F G P+R+ ++ + G+ +V W E++ +E + ++T+L AIGR T
Sbjct: 265 KFEAG-VPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTD 323
Query: 528 SLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLF 707
+ L GV+ + ++K+L ++T++P +YAIGDV+EG PELTP AI AGR+L++R+F
Sbjct: 324 DVGLTTIGVERAK-SKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIF 382
Query: 708 GGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGR-D 884
G+++L +YD +PTTVFTPLEYGC GLSEE+A+ ++G++++ +YH + PLE+T++ R D
Sbjct: 383 DGANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISERMD 442
Query: 885 ASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSE 1064
CY+KM+CLR + V+G H L PNAGEVTQGF + +K A A R +GIHPT +E
Sbjct: 443 KDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAE 502
Query: 1065 EVVKLRISKRSG 1100
L + K+ G
Sbjct: 503 NFTTLTLEKKEG 514
gb|AAD41826.1|AF148217_1 (AF148217) thioredoxin reductase [Caenorhabditis elegans]
Length = 667
Score = 337 bits (854), Expect = 2e-91
Identities = 172/361 (47%), Positives = 245/361 (67%), Gaps = 11/361 (3%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F + K K L+AD +I+TG RP+YP I G EY ITSDD+F
Sbjct: 288 YINSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYP-EIPGVKEYTITSDDLFQ 346
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L SPGKTL VGASYV+LECAGFL G G D T+M+RSI LRGFDQ M+ + +HM ++G
Sbjct: 347 LPYSPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHMIAYGM 406
Query: 378 RFLRGCAPSRVRRLPD------GQLQVTW----EDSTTGKEDTGTFDTVLWAIGRVPDTR 527
+F G P+R+ ++ + G+ +V W E++ +E + ++T+L AIGR T
Sbjct: 407 KFEAG-VPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTD 465
Query: 528 SLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLF 707
+ L GV+ + ++K+L ++T++P +YAIGDV+EG PELTP AI AGR+L++R+F
Sbjct: 466 DVGLTTIGVERAK-SKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIF 524
Query: 708 GGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGR-D 884
G+++L +YD +PTTVFTPLEYGC GLSEE+A+ ++G++++ +YH + PLE+T++ R D
Sbjct: 525 DGANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISERMD 584
Query: 885 ASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSE 1064
CY+KM+CLR + V+G H L PNAGEVTQGF + +K A A R +GIHPT +E
Sbjct: 585 KDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAE 644
Query: 1065 EVVKLRISKRSG 1100
L + K+ G
Sbjct: 645 NFTTLTLEKKEG 656
gb|AAD46625.1| (AF162693) thioredoxin reductase homolog [Caenorhabditis elegans]
Length = 525
Score = 337 bits (854), Expect = 2e-91
Identities = 172/361 (47%), Positives = 245/361 (67%), Gaps = 11/361 (3%)
Frame = +3
Query: 18 YFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFW 197
Y N F + K K L+AD +I+TG RP+YP I G EY ITSDD+F
Sbjct: 146 YINSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYP-EIPGVKEYTITSDDLFQ 204
Query: 198 LKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT 377
L SPGKTL VGASYV+LECAGFL G G D T+M+RSI LRGFDQ M+ + +HM ++G
Sbjct: 205 LPYSPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHMIAYGM 264
Query: 378 RFLRGCAPSRVRRLPD------GQLQVTW----EDSTTGKEDTGTFDTVLWAIGRVPDTR 527
+F G P+R+ ++ + G+ +V W E++ +E + ++T+L AIGR T
Sbjct: 265 KFEAG-VPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTD 323
Query: 528 SLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLF 707
+ L GV+ + ++K+L ++T++P +YAIGDV+EG PELTP AI AGR+L++R+F
Sbjct: 324 DVGLTTIGVERAK-SKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIF 382
Query: 708 GGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGR-D 884
G+++L +YD +PTTVFTPLEYGC GLSEE+A+ ++G++++ +YH + PLE+T++ R D
Sbjct: 383 DGANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISERMD 442
Query: 885 ASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSE 1064
CY+KM+CLR + V+G H L PNAGEVTQGF + +K A A R +GIHPT +E
Sbjct: 443 KDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAE 502
Query: 1065 EVVKLRISKRSG 1100
L + K+ G
Sbjct: 503 NFTTLTLEKKEG 514
pir||S57658 glutathione reductase - Plasmodium falciparum
>gi|886900|emb|CAA60574| (X87095) thioredoxin reductase
[Plasmodium falciparum]
Length = 541
Score = 304 bits (770), Expect = 1e-81
Identities = 164/369 (44%), Positives = 226/369 (60%), Gaps = 16/369 (4%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKG--GKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD 188
+Y N A D++TV KG KE ++ +I+IATG RP P +EGA E ITSDD
Sbjct: 155 KYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDD 214
Query: 189 IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 368
IF LK+ PGKTLVVGASYVALEC+GFL +G D T+ +RSI LRGFDQQ + V +M
Sbjct: 215 IFSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEE 274
Query: 369 HGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
G F G P ++ ++ D ++ V + D T+ +DTVL+AIGR D LNLE
Sbjct: 275 QGVMFKNGILPKKLTKMDD-KILVEFSDKTSE-----LYDTVLYAIGRKGDIDGLNLESL 328
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
++ + KI+ D T++P I+A+GDV E PEL P AI AG +L +RLF S ++M
Sbjct: 329 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIM 388
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD-------- 884
DY +PT+++TP+EYG G SEE+A +G+ +VEV+ + LE + R
Sbjct: 389 DYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKD 448
Query: 885 ------ASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGI 1046
+S C K+VCL+ V+G H++GPNAGEVTQG AL ++ +GI
Sbjct: 449 EYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGI 508
Query: 1047 HPTCSEEVVKLRISKRSGLDPTVTG 1121
HPT +E + L ++ SGL G
Sbjct: 509 HPTDAESFMNLFVTISSGLSYAAKG 533
pir||S55381 glutathione reductase - Plasmodium falciparum (fragment)
Length = 471
Score = 301 bits (762), Expect = 1e-80
Identities = 160/352 (45%), Positives = 220/352 (62%), Gaps = 16/352 (4%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKG--GKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD 188
+Y N A D++TV KG KE ++ +I+IATG RP P +EGA E ITSDD
Sbjct: 109 KYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDD 168
Query: 189 IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 368
IF LK+ PGKTLVVGASYVALEC+GFL +G D T+ +RSI LRGFDQQ + V +M
Sbjct: 169 IFSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEE 228
Query: 369 HGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
G F G P ++ ++ D ++ V + D T+ +DTVL+AIGR D LNLE
Sbjct: 229 QGVMFKNGILPKKLTKMDD-KILVEFSDKTSE-----LYDTVLYAIGRKGDIDGLNLESL 282
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
++ + KI+ D T++P I+A+GDV E PEL P AI AG +L +RLF S ++M
Sbjct: 283 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIM 342
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD-------- 884
DY +PT+++TP+EYG G SEE+A +G+ +VEV+ + LE + R
Sbjct: 343 DYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKD 402
Query: 885 ------ASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGI 1046
+S C K+VCL+ V+G H++GPNAGEVTQG AL ++ +GI
Sbjct: 403 EYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGI 462
Query: 1047 HPTCSEEV 1070
HPT +EE+
Sbjct: 463 HPTAAEEL 470
emb|CAA58583| (X83603) thioredoxin reductase [Plasmodium falciparum]
Length = 471
Score = 301 bits (762), Expect = 1e-80
Identities = 160/352 (45%), Positives = 220/352 (62%), Gaps = 16/352 (4%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKG--GKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD 188
+Y N A D++TV KG KE ++ +I+IATG RP P +EGA E ITSDD
Sbjct: 109 KYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDD 168
Query: 189 IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 368
IF LK+ PGKTLVVGASYVALEC+GFL +G D T+ +RSI LRGFDQQ + V +M
Sbjct: 169 IFSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEE 228
Query: 369 HGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
G F G P ++ ++ D ++ V + D T+ +DTVL+AIGR D LNLE
Sbjct: 229 QGVMFKNGILPKKLTKMDD-KILVEFSDKTSE-----LYDTVLYAIGRKGDIDGLNLESL 282
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLM 728
++ + KI+ D T++P I+A+GDV E PEL P AI AG +L +RLF S ++M
Sbjct: 283 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIM 342
Query: 729 DYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD-------- 884
DY +PT+++TP+EYG G SEE+A +G+ +VEV+ + LE + R
Sbjct: 343 DYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKD 402
Query: 885 ------ASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGI 1046
+S C K+VCL+ V+G H++GPNAGEVTQG AL ++ +GI
Sbjct: 403 EYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGI 462
Query: 1047 HPTCSEEV 1070
HPT +EE+
Sbjct: 463 HPTAAEEL 470
sp|P91938|GSHR_DROME GLUTATHIONE REDUCTASE (GR) (GRASE) >gi|1857433 (U81995) glutathione
reductase [Drosophila melanogaster]
Length = 476
Score = 293 bits (741), Expect = 3e-78
Identities = 180/370 (48%), Positives = 226/370 (60%), Gaps = 4/370 (1%)
Frame = +3
Query: 15 EYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
EY N SFV C K G E ++A +IA G RPRYP I GA E G TSDD+F
Sbjct: 120 EYINGLGSFVTRTHCCPSMKSG-ERTITAQTFVIAVG-RPRYPD-IPGAAEIGTTSDDLF 176
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHG 374
L + GKTLVVGA Y+ LECAGFL G+G T +M+RSI LRGFDQQM+ +V M G
Sbjct: 177 SL-DREGKTLVVGAGYIGLECAGFLKGLGYGT-VMVRSIVLRGFDQQMAELVAASMEERG 234
Query: 375 TRFLRGCAPSRVRRLPDG---QLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEK 545
FL R R D + ++T TT LWAIGR SLNL
Sbjct: 235 IPFLADV--DRCREADDAAAREYRLTQIRFTTSHHR-------LWAIGRKGLCDSLNLPM 285
Query: 546 AGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDL 725
+ D KI VDS+EAT+VPHIYA+GD++ G+PELTP A++AGRLL +RLFGGS+
Sbjct: 286 PALTVQKD--KIPVDSQEATNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLFGGSTQS 343
Query: 726 MDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVK 905
MDY +V TTVF+ GL+EE+A + + +EV+H +YKP EF + + CY+K
Sbjct: 344 MDYKDVATTVFS-WSTSASGLAEEDA-SSSSEPRIEVFHGYYKPTEFFIPQKSVRYCYLK 401
Query: 906 MVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRI 1085
V R Q V GLH++GP AGEV QGFA +K G + ++ TVGIHPT +EE +L I
Sbjct: 402 AVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTLT-LINTVGIHPTTAEEFTRLAI 460
Query: 1086 SK-RSGLDPTVTGC 1124
+K RSGLDPT C
Sbjct: 461 TKPRSGLDPTPASC 474
sp|P43783|GSHR_HAEIN GLUTATHIONE REDUCTASE (GR) (GRASE) >gi|1074147|pir||A64052
glutathione reductase (NADPH) (EC 1.6.4.2) - Haemophilus
influenzae (strain Rd KW20) >gi|644854 (U20229)
glutathione reductase [Haemophilus influenzae]
>gi|1573119 (U32702) glutathione reductase (gor)
[Haemophilus influenzae Rd]
Length = 456
Score = 241 bits (608), Expect = 1e-62
Identities = 142/348 (40%), Positives = 210/348 (59%), Gaps = 2/348 (0%)
Frame = +3
Query: 39 FVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGK 218
FVD HT+ G + ++ADHI+IATGGRP Y +I+G EYGI SD F L E P +
Sbjct: 117 FVDAHTIEVTLADGTKEQVTADHILIATGGRP-YRPNIKGQ-EYGIDSDGFFALTELPKR 174
Query: 219 TLVVGASYVALECAGFLTGIGLDTTIMMRS-IPLRGFDQQMSSMVIEHMASHGTRFLRGC 395
V+GA Y+A+E +G L +G++T +++R P+R D + ++E +A G +
Sbjct: 175 AAVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNS 234
Query: 396 APSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQ 575
PS + + DG L V + G+ D T D V+WA GRVP T + LE AGV+T+ +
Sbjct: 235 TPSEIVKNADGSLTVRCD----GQSDV-TVDCVIWAAGRVPTTDKIGLENAGVETN-EHG 288
Query: 576 KILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGS-SDLMDYDNVPTT 752
+ VD + T+V IYA+GD++E ELTP A+ AGR L +RLF ++ +DY VPT
Sbjct: 289 YVKVDKYQNTNVKGIYAVGDIIENGIELTPVAVAAGRRLSERLFNNKPTEYLDYSLVPTV 348
Query: 753 VFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQ 932
VF+ G VGL+E +A+ ++G E+V+VY + + + +T + C +K+VC+ + +
Sbjct: 349 VFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAM-YTAVTQHRQPCKMKLVCVGKDEK 407
Query: 933 LVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
+V GLH +G E+ QGFA+ IK GA+ A TV IHPT SEE V +R
Sbjct: 408 VV-GLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 456
pir||S41386 glutathione reductase (NADPH) (EC 1.6.4.2) - Streptococcus
thermophilus >gi|443691 (L27672) glutathione reductase
[Streptococcus thermophilus] >gi|444035|emb|CAA82630|
(Z29494) glutathione reductase [Streptococcus
thermophilus]
Length = 450
Score = 239 bits (604), Expect = 4e-62
Identities = 145/350 (41%), Positives = 211/350 (59%), Gaps = 2/350 (0%)
Frame = +3
Query: 33 ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESP 212
A FVD HTV + L +A HI+IATGG P YP +I G+ EYGITSD F L E P
Sbjct: 115 ARFVDPHTVEVAGE-----LYTAPHILIATGGHPLYP-NIPGS-EYGITSDGFFELDEVP 167
Query: 213 GKTLVVGASYVALECAGFLTGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLR 389
+T V+GA Y+A+E AG L +G DT + +R PLR FD+ + ++++ MA G
Sbjct: 168 KRTAVIGAGYIAVEVAGVLNALGSDTHLFVRKDRPLRTFDKDIIDVLVDEMAKSGPTLHM 227
Query: 390 GCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPD 569
+ V + D L +++++ E+T T D ++WA+GR +T LEK GV+ + +
Sbjct: 228 HANATEVVKNADDSLTISFDN-----EETITVDCLIWAVGRAANTSGFGLEKTGVELT-E 281
Query: 570 TQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDL-MDYDNVP 746
I D E TSVP IYA+GDV G+ +LTP A+ AGR L +RLF D +DY +V
Sbjct: 282 RGNIYSDEFENTSVPGIYALGDVT-GKLDLTPVAVKAGRQLSERLFNNKVDAKLDYTDVA 340
Query: 747 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREP 926
T VF+ G +GL+EE+A+A++G E+++VY + + P+ +T G + +K+V L E
Sbjct: 341 TVVFSHPAIGAIGLTEEKAIAKYGAENIKVYKSSFTPM-YTALGDNRQLSTMKLVTLGE- 398
Query: 927 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
+ ++GLH +G E+ QGF++ IK GA+ A TV IHPT SEE V +R
Sbjct: 399 DEKIIGLHGIGYGVDEMIQGFSVAIKMGATKADFDNTVAIHPTGSEEFVTMR 450
sp|P47791|GSHR_MOUSE GLUTATHIONE REDUCTASE (GR) (GRASE) >gi|481814|pir||S39494 glutathione
reductase (NADPH) (EC 1.6.4.2) - mouse (fragment)
Length = 466
Score = 235 bits (594), Expect = 6e-61
Identities = 150/358 (41%), Positives = 214/358 (58%), Gaps = 9/358 (2%)
Frame = +3
Query: 9 HEEYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYP--THIEGALEYGITS 182
H E + A+F D G K +A HI+IATGG P P + I GA GITS
Sbjct: 110 HIEIIHGYATFADGPRPTVEVNGKK---FTAPHILIATGGVPTVPHESQIPGA-SLGITS 165
Query: 183 DDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIP-LRGFDQQMSSMVIEH 359
D F L++ P ++++VGA Y+A+E AG L+ +G T++M+R LR FD +SS E
Sbjct: 166 DGFFQLEDLPSRSVIVGAGYIAVEIAGILSALGSKTSLMIRHDKVLRNFDSLISSKCTEE 225
Query: 360 MASHGTRFLRGCAPSRVRRLPDG-QLQVTWEDSTTGKEDTGTF----DTVLWAIGRVPDT 524
+ + G L+ V++ G +LQV S G++ T T D +LWAIGR P++
Sbjct: 226 LENAGVEVLKFTQVKEVKKTSSGLELQVV--TSVPGRKPTTTVIPDVDCLLWAIGRDPNS 283
Query: 525 RSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRL 704
+ LNL K G+ T + ILVD + T+V +YA+GDV G+ LTP AI AGR L RL
Sbjct: 284 KGLNLNKVGIQTD-EKGHILVDEFQNTNVKGVYAVGDVC-GKALLTPVAIAAGRKLAHRL 341
Query: 705 FGGSSDL-MDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGR 881
F D +DYDN+PT VF+ G VGL+E+EAV ++G+++V++Y + P+ V R
Sbjct: 342 FECKQDSKLDYDNIPTVVFSHPPIGTVGLTEDEAVHKYGKDNVKIYSTAFTPMYHAVTTR 401
Query: 882 DASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCS 1061
++C +KMVC + + V+G+H G E+ QGFA+ +K GA+ A TV IHPT S
Sbjct: 402 -KTKCVMKMVCANK-EEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSS 459
Query: 1062 EEVVKLR 1082
EE+V LR
Sbjct: 460 EELVTLR 466
pdb|1DNC| Human Glutathione Reductase Modified By Diglutathione-Dinitroso-Iron
Length = 478
Score = 234 bits (590), Expect = 2e-60
Identities = 142/329 (43%), Positives = 203/329 (61%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 148 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 206
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 207 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 265
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 266 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 324
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 325 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 383
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMVC + + V+G+H G
Sbjct: 384 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK-EEKVVGIHMQGLGCD 441
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 442 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 478
pdb|1GRT| Human Glutathione Reductase A34eR37W MUTANT
Length = 478
Score = 234 bits (590), Expect = 2e-60
Identities = 142/329 (43%), Positives = 203/329 (61%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 148 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 206
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 207 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 265
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 266 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 324
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 325 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 383
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMVC + + V+G+H G
Sbjct: 384 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK-EEKVVGIHMQGLGCD 441
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 442 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 478
pdb|3GRS| Glutathione Reductase (E.C.1.6.4.2), Oxidized Form (E)
>gi|231021|pdb|4GR1| Glutathione Reductase (E.C.1.6.4.2)
Oxidized Form Complexed With Retro-Gssg
>gi|494055|pdb|1GRA| Glutathione Reductase (E.C.1.6.4.2)
(Oxidized) Complex With Glutathione Disulfide And Nadp+
>gi|494056|pdb|1GRB| Glutathione Reductase (E.C.1.6.4.2)
(Oxidized) Complex With Nadh And Phosphate
>gi|494057|pdb|1GRE| Glutathione Reductase (E.C.1.6.4.2)
Complex With Covalently Bound Glutathione And Phosphate
>gi|494058|pdb|1GRF| Glutathione Reductase (E.C.1.6.4.2)
Carboxymethylated At Cys 58 Complex With Phosphate
>gi|494059|pdb|1GRG| Glutathione Reductase (E.C.1.6.4.2)
Modified By Bcnu (1,3-Bis(2-Chloroethyl)-1-Nitrosourea)
At Cys 58 Complexed With Phosphate >gi|494060|pdb|1GRH|
Glutathione Reductase (E.C.1.6.4.2) Modified By Hecnu
(1-(2-Chloroethyl)-3-(2-Hydroxyethyl)-1-Nitrosourea) At
Cys 58 Complexed With Phosphate >gi|5821922|pdb|1BWC|A
Chain A, Ajoene Is An Inhibitor And Subversive Substrate
Of Human Glutathione Reductase And T. Cruzi Trypanothione
Reductase: Crystallographic, Kinetic, And Spectroscopic
Studies
Length = 478
Score = 234 bits (590), Expect = 2e-60
Identities = 142/329 (43%), Positives = 203/329 (61%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 148 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 206
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 207 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 265
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 266 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 324
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 325 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 383
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMVC + + V+G+H G
Sbjct: 384 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK-EEKVVGIHMQGLGCD 441
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 442 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 478
pdb|2GRT| Human Glutathione Reductase A34e, R37w Mutant, Oxidized Glutathione
Complex >gi|2392749|pdb|3GRT| Human Glutathione
Reductase A34e, R37w Mutant, Oxidized Trypanothione
Complex >gi|2392787|pdb|4GRT| Human Glutathione
Reductase A34e, R37w Mutant, Mixed Disulfide Between
Trypanothione And The Enzyme >gi|2392798|pdb|5GRT| Human
Glutathione Reductase A34e, R37w Mutant,
Glutathionylspermidine Complex
Length = 461
Score = 234 bits (590), Expect = 2e-60
Identities = 142/329 (43%), Positives = 203/329 (61%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 131 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 189
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 190 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 248
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 249 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 307
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 308 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 366
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMVC + + V+G+H G
Sbjct: 367 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK-EEKVVGIHMQGLGCD 424
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 425 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 461
pdb|1XAN| Human Glutathione Reductase In Complex With A Xanthene Inhibitor
Length = 461
Score = 234 bits (590), Expect = 2e-60
Identities = 142/329 (43%), Positives = 203/329 (61%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 131 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 189
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 190 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 248
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 249 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 307
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 308 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 366
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMVC + + V+G+H G
Sbjct: 367 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK-EEKVVGIHMQGLGCD 424
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 425 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 461
sp|P00390|GSHR_HUMAN GLUTATHIONE REDUCTASE (GR) (GRASE) >gi|1070445|pir||RDHUU glutathione
reductase (NADPH) (EC 1.6.4.2) - human
>gi|31825|emb|CAA33744| (X15722) glutathione reductase
(AA 1-479) [Homo sapiens]
>gi|6635853|gb|AAF20007.1|AF215848_1 (AF215848)
glutathione reductase [Homo sapiens]
Length = 479
Score = 234 bits (590), Expect = 2e-60
Identities = 142/329 (43%), Positives = 203/329 (61%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 149 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 207
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 208 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 266
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 267 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 325
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 326 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 384
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMVC + + V+G+H G
Sbjct: 385 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANK-EEKVVGIHMQGLGCD 442
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 443 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 479
dbj|BAA21419| (AB004537) glutathione reductase [Schizosaccharomyces pombe]
>gi|5679726|emb|CAB51766.1| (AL109652) glutathione
reductase [Schizosaccharomyces pombe]
Length = 464
Score = 232 bits (586), Expect = 5e-60
Identities = 143/354 (40%), Positives = 206/354 (57%), Gaps = 5/354 (1%)
Frame = +3
Query: 18 YFNIKASFVDEHTVC-GVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
Y + ASFV V + G + SA +I+IA GG P +P+HI GA EYGI SD F
Sbjct: 114 YISGHASFVSPTEVAVDMNDGSGTQVFSAKYILIAVGGHPIWPSHIPGA-EYGIDSDGFF 172
Query: 195 WLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIP-LRGFDQQMSSMVIEHMASH 371
L+ P + +VGA Y+A+E AG +G +T + +R LR FD +S +++H
Sbjct: 173 ELESQPKRVAIVGAGYIAVELAGVFAALGTETHMFIRQSKFLRKFDPIISDGIMDHFQHI 232
Query: 372 GTRFLRGCAP-SRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKA 548
G +V +LP G+L + +D +T DT+LWAIGR P + L LEKA
Sbjct: 233 GINVHTNSLEFKKVEKLPSGELCIHQQDGSTFN-----VDTLLWAIGRAPKIQGLRLEKA 287
Query: 549 GVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDL- 725
GV T P+ I+ D+ + T+VP + ++GDV G+ ELTP AI AGR L RLFGG D
Sbjct: 288 GVKTLPNGI-IIADTYQRTNVPTVLSLGDVC-GKLELTPVAIAAGRRLSDRLFGGIKDAH 345
Query: 726 MDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFT-VAGRDASQCYV 902
+DY+ VP+ VF E G +GL+E+EA+ ++G+ ++VY+ + L ++ V D
Sbjct: 346 LDYEEVPSVVFAHPEAGTIGLTEQEAIDKYGESQIKVYNTKFNGLNYSMVEQEDKVPTTY 405
Query: 903 KMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKL 1079
K+VC P Q V+GLH +G + E+ QGF + IK GA+ + V IHPT +EE+V L
Sbjct: 406 KLVCAG-PLQKVVGLHLVGDFSAEILQGFGVAIKMGATKSDFDSCVAIHPTSAEELVTL 463
pdb|1GSN| Human Glutathione Reductase Modified By Dinitrosoglutathione
Length = 478
Score = 230 bits (580), Expect = 3e-59
Identities = 141/329 (42%), Positives = 202/329 (60%), Gaps = 8/329 (2%)
Frame = +3
Query: 96 SADHIIIATGGRPRYP--THIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL 269
+A HI+IATGG P P + I GA GITSD F L+E PG++++VGA Y+A+E AG L
Sbjct: 148 TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 206
Query: 270 TGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTW 446
+ +G T++M+R LR FD +S+ E + + G L+ V++ G L+V+
Sbjct: 207 SALGSKTSLMIRHDKVLRSFDSMISTNXTEELENAGVEVLKFSQVKEVKKTLSG-LEVSM 265
Query: 447 EDSTTGKEDTGTF----DTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVP 614
+ G+ T D +LWAIGRVP+T+ L+L K G+ T D I+VD + T+V
Sbjct: 266 VTAVPGRLPVMTMIPDVDXLLWAIGRVPNTKDLSLNKLGIQTD-DKGHIIVDEFQNTNVK 324
Query: 615 HIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVPTTVFTPLEYGCVGLS 791
IYA+GDV G+ LTP AI AGR L RLF D +DY+N+PT VF+ G VGL+
Sbjct: 325 GIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLT 383
Query: 792 EEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAG 971
E+EA+ ++G E+V+ Y + P+ V R ++C +KMV + + V+G+H G
Sbjct: 384 EDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVXANK-EEKVVGIHMQGLGCD 441
Query: 972 EVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
E+ QGFA+ +K GA+ A TV IHPT SEE+V LR
Sbjct: 442 EMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 478
sp|P06715|GSHR_ECOLI GLUTATHIONE REDUCTASE (GR) (GRASE) >gi|66121|pir||RDECU glutathione
reductase (NADPH) (EC 1.6.4.2) - Escherichia coli
>gi|809418|pdb|1GER|A Escherichia coli
>gi|809419|pdb|1GER|B Escherichia coli
>gi|809422|pdb|1GET|A Escherichia coli
>gi|809423|pdb|1GET|B Escherichia coli >gi|146248
(M13141) glutathione reductase (EC 1.6.4.2) [Escherichia
coli] >gi|466637 (U00039) glutathione oxidoreductase
[Escherichia coli] >gi|1789915 (AE000426) glutathione
oxidoreductase [Escherichia coli]
Length = 450
Score = 226 bits (569), Expect = 5e-58
Identities = 142/350 (40%), Positives = 203/350 (57%), Gaps = 2/350 (0%)
Frame = +3
Query: 33 ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESP 212
A FVD T+ G+ I +ADHI+IATGGRP +P I G +EYGI SD F L P
Sbjct: 115 ARFVDAKTL---EVNGETI--TADHILIATGGRPSHPD-IPG-VEYGIDSDGFFALPALP 167
Query: 213 GKTLVVGASYVALECAGFLTGIGLDTTIMMRS-IPLRGFDQQMSSMVIEHMASHGTRFLR 389
+ VVGA Y+A+E AG + G+G T + +R PLR FD +S ++E M + G +
Sbjct: 168 ERVAVVGAGYIAVELAGVINGLGAKTHLFVRKHAPLRSFDPMISETLVEVMNAEGPQLHT 227
Query: 390 GCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPD 569
P V + DG L + ED G+ + T D ++WAIGR P ++NLE AGV T+ +
Sbjct: 228 NAIPKAVVKNTDGSLTLELED---GRSE--TVDCLIWAIGREPANDNINLEAAGVKTN-E 281
Query: 570 TQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSD-LMDYDNVP 746
I+VD + T++ IYA+GD G ELTP A+ AGR L +RLF D +DY N+P
Sbjct: 282 KGYIVVDKYQNTNIEGIYAVGDNT-GAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIP 340
Query: 747 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREP 926
T VF+ G VGL+E +A ++G + V+VY + + + +T C +K+VC+
Sbjct: 341 TVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAM-YTAVTTHRQPCRMKLVCVGSE 399
Query: 927 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
++V G+H +G E+ QGFA+ +K GA+ TV IHPT +EE V +R
Sbjct: 400 EKIV-GIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR 450
gi|1657632 (U73174) glutathione reductase [Rattus norvegicus]
Length = 420
Score = 225 bits (568), Expect = 6e-58
Identities = 147/358 (41%), Positives = 211/358 (58%), Gaps = 12/358 (3%)
Frame = +3
Query: 9 HEEYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYP--THIEGALEYGITS 182
H E + A+F D G K +A HI+IATGG P P I GA GITS
Sbjct: 60 HIEVIHGYATFRDGPQPTAEVNGKK---FTAPHILIATGGVPTVPHENQIPGA-SLGITS 115
Query: 183 DDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIP-LRGFDQQMSSMVIEH 359
D F L++ P ++++VGA Y+A+E AG L+ +G T++M+R LR FD +SS E
Sbjct: 116 DGFFQLEDLPSRSVIVGAGYIAVEIAGILSALGSKTSLMIRHDKVLRSFDSLISSNCTEE 175
Query: 360 MASHG----TRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGT----FDTVLWAIGRV 515
+ + G + V++ G L++ + G++ T T D +LWAIGR
Sbjct: 176 LENAGGVEVLTVKKFSQVKEVKKTSSG-LELHVVTALPGRKPTVTTIPDVDCLLWAIGRD 234
Query: 516 PDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLV 695
P+++ LNL K G+ T D ILVD + T+V +YA+GDV G+ LTP AI AGR L
Sbjct: 235 PNSKGLNLNKLGIQTD-DKGHILVDEFQNTNVKGVYAVGDVC-GKALLTPVAIAAGRKLA 292
Query: 696 QRLFGGSSDL-MDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTV 872
RLF G D +DYDN+PT VF+ G VGL+E+EAV ++G+++V++Y + P+ V
Sbjct: 293 HRLFEGKEDSRLDYDNIPTVVFSHPPIGTVGLTEDEAVHKYGKDNVKIYSTAFTPMYHAV 352
Query: 873 AGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 1052
R ++C +KMVC + + V+G+H G E+ QGFA+ +K GA+ A V IHP
Sbjct: 353 TTR-KTKCVMKMVCANK-EEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNRVAIHP 410
Query: 1053 TCSEEVVKLR 1082
T SEE+V LR
Sbjct: 411 TSSEELVTLR 420
gi|1778071 (U63845) glutathione reductase [Schizosaccharomyces pombe]
Length = 465
Score = 220 bits (555), Expect = 2e-56
Identities = 142/354 (40%), Positives = 204/354 (57%), Gaps = 6/354 (1%)
Frame = +3
Query: 18 YFNIKASFVDEHTVC-GVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 194
Y + ASFV V + G + SA +I+IA GG P +P+HI GA EYGI SD F
Sbjct: 114 YISGHASFVSPTEVAVDMNDGSGTQVFSAKYILIAVGGHPIWPSHIPGA-EYGIDSDGFF 172
Query: 195 WLKESPGKT-LVVGASYVALECAGFLTGIGLDTTIMMRSIP-LRGFDQQMSSMVIEHMAS 368
L+ P + +VVGA Y+A+E AG +G +T + +R LR FD +S +++H
Sbjct: 173 ELESQPKRVAIVVGAGYIAVELAGVFAALGTETHMFIRQSKFLRKFDPIISDGIMDHFQH 232
Query: 369 HGTRFLRGCAP-SRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEK 545
G +V +LP G+L + +D +T DT+LWAIGR P + L LEK
Sbjct: 233 IGINVHTNSLEFKKVEKLPSGELCIHQQDGSTFN-----VDTLLWAIGRAPKIQGLRLEK 287
Query: 546 AGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDL 725
AGV T P+ I+ D+ + T+VP + ++GDV G+ ELTP AI AGR L RLFGG D
Sbjct: 288 AGVKTLPNGI-IIADTYQRTNVPTVLSLGDVC-GKLELTPVAIAAGRRLSDRLFGGIKDA 345
Query: 726 -MDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFT-VAGRDASQCY 899
+DY+ VP+ VF E G +GL+E+EA+ ++G+ ++VY+ + L ++ V D
Sbjct: 346 HLDYEEVPSVVFAHPEAGTIGLTEQEAIDKYGESQIKVYNTKFNGLNYSMVEQEDKVPTT 405
Query: 900 VKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKL 1079
K+VC P Q V+G F + E+ QGF + IK GA+ + V IHPT +EE+V L
Sbjct: 406 YKLVC-AGPLQKVVGPTFSWRFSAEILQGFGVAIKMGATKSDFDSCVAIHPTSAEELVTL 464
pdb|1GES|A Escherichia coli >gi|809421|pdb|1GES|B Escherichia coli
>gi|809424|pdb|1GEU|A Escherichia coli
>gi|809425|pdb|1GEU|B Escherichia coli
Length = 450
Score = 218 bits (550), Expect = 8e-56
Identities = 139/350 (39%), Positives = 199/350 (56%), Gaps = 2/350 (0%)
Frame = +3
Query: 33 ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESP 212
A FVD T+ G+ I +ADHI+IATGGRP +P I G +EYGI SD F L P
Sbjct: 115 ARFVDAKTL---EVNGETI--TADHILIATGGRPSHPD-IPG-VEYGIDSDGFFALPALP 167
Query: 213 GKTLVVGASYVALECAGFLTGIGLDTTIM-MRSIPLRGFDQQMSSMVIEHMASHGTRFLR 389
+ VVGA Y+ +E G + G+G T + M PL FD +S ++E M + G +
Sbjct: 168 ERVAVVGAGYIGVELGGVINGLGAKTHLFEMFDAPLPSFDPMISETLVEVMNAEGPQLHT 227
Query: 390 GCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPD 569
P V + DG L + ED G+ +T D ++WAIGR P ++NLE AGV T+ +
Sbjct: 228 NAIPKAVVKNTDGSLTLELED---GRSET--VDCLIWAIGREPANDNINLEAAGVKTN-E 281
Query: 570 TQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDL-MDYDNVP 746
I+VD + T++ IYA+GD G ELTP A+ AGR L +RLF D +DY N+P
Sbjct: 282 KGYIVVDKYQNTNIEGIYAVGDNT-GAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIP 340
Query: 747 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREP 926
T VF+ G VGL+E +A ++G + V+VY + + + +T C +K+VC+
Sbjct: 341 TVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAM-YTAVTTHRQPCRMKLVCVGSE 399
Query: 927 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
++V G+H +G E+ QGFA+ +K GA+ TV IHPT +EE V +R
Sbjct: 400 EKIV-GIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR 450
dbj|BAA76640.1| (AB019579) glutathione reductase (GR) [Streptococcus mutans]
Length = 450
Score = 213 bits (536), Expect = 4e-54
Identities = 141/350 (40%), Positives = 198/350 (56%), Gaps = 2/350 (0%)
Frame = +3
Query: 33 ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESP 212
A+FVD HTV G+ +A HI+IATGG P I G+ EYGITSD F L P
Sbjct: 115 ATFVDAHTV---EVAGEHY--TAPHILIATGGHALLPD-IPGS-EYGITSDGFFELDAIP 167
Query: 213 GKTLVVGASYVALECAGFLTGIGLDTTIMMR-SIPLRGFDQQMSSMVIEHMASHGTRFLR 389
+T VVGA Y+A+E +G L +G +T + +R PLR FD+++ +++ M G
Sbjct: 168 KRTAVVGAGYIAVEISGVLHALGGETHLFVRRDRPLRKFDKEIVGTLVDEMKKDGPHLHT 227
Query: 390 GCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPD 569
P V + D L + E+ + T DT++WAIGR +T+ NLE GV T
Sbjct: 228 FSVPKEVIKNTDNSLTLILENG-----EEYTVDTLIWAIGRAANTKGFNLEVTGV-TLDS 281
Query: 570 TQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDL-MDYDNVP 746
I D+ E T+V +YA+GDV G+ ELTP A+ AGR L +RLF MDY +V
Sbjct: 282 RGFIATDAFENTNVEGLYALGDV-NGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVA 340
Query: 747 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREP 926
T +F+ G +GLSEE A+ ++G+E+V VY + + + +T C +K+V + E
Sbjct: 341 TVIFSHPVIGSIGLSEEVALDQYGEENVTVYRSTFTSM-YTAVTSHRQACKMKLVTVGED 399
Query: 927 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLR 1082
++V GLH +G E+ QGFA+ IK GA+ A TV IHPT SEE V +R
Sbjct: 400 EKIV-GLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 450
pir||S18973 glutathione reductase (NADPH) (EC 1.6.4.2) - garden pea
>gi|1345568|emb|CAA42921| (X60373) glutathione reductase
(NADPH) [Pisum sativum]
Length = 562
Score = 210 bits (529), Expect = 2e-53
Identities = 136/355 (38%), Positives = 192/355 (53%), Gaps = 1/355 (0%)
Frame = +3
Query: 30 KASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKES 209
+ VD HTV K L SA HI+++ GGRP P I G EY I SD L
Sbjct: 203 RGKIVDAHTVDVDGK-----LYSAKHILVSVGGRPFIPD-IPGK-EYAIDSDAALDLPSK 255
Query: 210 PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIP-LRGFDQQMSSMVIEHMASHGTRFL 386
P K +VG Y+ALE AG G+ + + +R LRGFD+++ V E+MA G F
Sbjct: 256 PQKIAIVGGGYIALEFAGIFNGLKSEVHVFIRQKKVLRGFDEEIRDFVAENMALRGIEFH 315
Query: 387 RGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSP 566
+P + + DG L + T K F +++A GR P+T+ L LE GV +
Sbjct: 316 TEESPVAITKAADGSLSLK-----TNKGTEEGFSHIMFATGRSPNTKDLGLESVGVKVAK 370
Query: 567 DTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNVP 746
D I VD TSVP I+AIGD R LTP A+M G L + LF DY +P
Sbjct: 371 DGS-IEVDEYSQTSVPSIWAIGDATN-RVNLTPVALMEGVALAKTLFQNEPTKPDYRAIP 428
Query: 747 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREP 926
+ VF+ G VGL+EE+A ++G ++V+ A+++P++ T++G + ++K++ E
Sbjct: 429 SAVFSQPPIGGVGLTEEQAAEQYGD--IDVFTANFRPMKATLSGLP-DRVFMKLIVSAET 485
Query: 927 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
+VLGLH G +A E+ QGFA+GIK G + A TVGIHPT +EE V +R R
Sbjct: 486 -NVVLGLHMCGEDAAEIAQGFAVGIKAGLTKADFDATVGIHPTAAEEFVTMRTPTR 540
sp|P27456|GSHC_PEA GLUTATHIONE REDUCTASE, CHLOROPLAST/MITOCHONDRIAL PRECURSOR (GR)
(GRASE) (GOR1) >gi|975704|emb|CAA62482| (X90996)
glutathione reductase (NADPH) [Pisum sativum]
Length = 552
Score = 210 bits (529), Expect = 2e-53
Identities = 136/355 (38%), Positives = 192/355 (53%), Gaps = 1/355 (0%)
Frame = +3
Query: 30 KASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKES 209
+ VD HTV K L SA HI+++ GGRP P I G EY I SD L
Sbjct: 193 RGKIVDAHTVDVDGK-----LYSAKHILVSVGGRPFIPD-IPGK-EYAIDSDAALDLPSK 245
Query: 210 PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIP-LRGFDQQMSSMVIEHMASHGTRFL 386
P K +VG Y+ALE AG G+ + + +R LRGFD+++ V E+MA G F
Sbjct: 246 PQKIAIVGGGYIALEFAGIFNGLKSEVHVFIRQKKVLRGFDEEIRDFVAENMALRGIEFH 305
Query: 387 RGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSP 566
+P + + DG L + T K F +++A GR P+T+ L LE GV +
Sbjct: 306 TEESPVAITKAADGSLSLK-----TNKGTEEGFSHIMFATGRSPNTKDLGLESVGVKVAK 360
Query: 567 DTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNVP 746
D I VD TSVP I+AIGD R LTP A+M G L + LF DY +P
Sbjct: 361 DGS-IEVDEYSQTSVPSIWAIGDATN-RVNLTPVALMEGVALAKTLFQNEPTKPDYRAIP 418
Query: 747 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREP 926
+ VF+ G VGL+EE+A ++G ++V+ A+++P++ T++G + ++K++ E
Sbjct: 419 SAVFSQPPIGGVGLTEEQAAEQYGD--IDVFTANFRPMKATLSGLP-DRVFMKLIVSAET 475
Query: 927 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKR 1094
+VLGLH G +A E+ QGFA+GIK G + A TVGIHPT +EE V +R R
Sbjct: 476 -NVVLGLHMCGEDAAEIAQGFAVGIKAGLTKADFDATVGIHPTAAEEFVTMRTPTR 530
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Dec 29, 1999 2:49 PM
Number of letters in database: 135,346,764
Number of sequences in database: 440,253
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 446632890
Number of Sequences: 440253
Number of extensions: 11511883
Number of successful extensions: 41849
Number of sequences better than 10.0: 476
Number of HSP's better than 10.0 without gapping: 194
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 40793
Number of HSP's gapped (non-prelim): 459
length of query: 506
length of database: 135,346,764
effective HSP length: 56
effective length of query: 449
effective length of database: 110,692,596
effective search space: 49700975604
effective search space used: 49700975604
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 72 (32.5 bits)
