Score E
Sequences producing significant alignments: (bits) Value
emb|CAB63796.1| (AL135751) putative transmembrane protein; ... 788 0.0
ref|NP_012476.1|YHC3| Yhc3p >gi|1352987|sp|P47040|BTN1_YEAS... 262 4e-69
gi|3063665 (AF058447) Btn1p [Saccharomyces cerevisiae] 260 1e-68
gi|2388631 (U92811) CLN3 [Mus musculus] 177 1e-43
sp|Q29611|CLN3_CANFA CLN3 PROTEIN (BATTENIN) >gi|1478040 (L... 177 2e-43
sp|Q61124|CLN3_MOUSE CLN3 PROTEIN (BATTENIN) >gi|1736932 (U... 176 4e-43
gi|1519717 (U68064) CLN3 [Mus musculus] 175 6e-43
ref|NP_000077.1|PCLN3| ceroid-lipofuscinosis, neuronal 3, j... 169 3e-41
gb|AAD51488.1|AF077966_1 (AF077966) CLN3 protein [Homo sapi... 168 8e-41
gi|1703588 (U80439) C01G8.2 [Caenorhabditis elegans] 168 1e-40
gi|2388633 (U92812) CLN3 [Oryctolagus cuniculus] 162 6e-39
emb|CAB01140.1| (Z77656) predicted using Genefinder; Simila... 160 2e-38
gb|AAD51494.1|AF077972_1 (AF077972) CLN3 protein [Homo sapi... 146 2e-34
gb|AAD51482.1|AF077960_1 (AF077960) CLN3 protein [Homo sapi... 122 7e-27
gi|4102731 (AF015594) CLN3 protein [Homo sapiens] 120 2e-26
gi|4102733 (AF015595) CLN3 protein [Homo sapiens] 113 2e-24
gb|AAD51485.1|AF077963_1 (AF077963) CLN3 protein [Homo sapi... 107 2e-22
gi|3329658 (AF078788) similar to Batten disease-related pro... 92 6e-18
gi|4102739 (AF015598) CLN3 protein [Homo sapiens] 90 2e-17
gi|4102735 (AF015596) CLN3 protein [Homo sapiens] 64 3e-09
gb|AAD51487.1|AF077965_1 (AF077965) CLN3 protein [Homo sapi... 45 9e-04
gi|1478042 (L76282) CLN3 gene product [Canis familiaris] 44 0.002
gi|4102743 (AF015600) CLN3 protein [Homo sapiens] 42 0.008
emb|CAA04021| (AJ000346) NapC protein [Enterococcus hirae] 39 0.051
gb|AAD30608.1|AC007369_18 (AC007369) Sugar transporter [Ara... 36 0.44
emb|CAB07312.1| (Z92825) predicted using Genefinder [Caenor... 35 0.98
sp|Q36428|NU5M_LOCMI NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5 35 1.3
gnl|NCBI_MITO|ND5_10712 NADH dehydrogenase subunit 5 >gi|11... 35 1.3
gnl|NCBI_MITO|ND6_10015 NADH dehydrogenase subunit 6 >gi|12... 34 1.7
sp|Q43975|PCAK_ACICA 4-HYDROXYBENZOATE TRANSPORTER >gi|3172... 34 2.9
emb|CAA74938| (Y14599) hypothetical protein [Staphylococcus... 34 2.9
emb|CAB16543.1| (Z99286) Y7A9C.3 [Caenorhabditis elegans] 34 2.9
gi|1407629 (U49052) cytochrome oxidase subunit I [Euglena g... 34 2.9
sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 ... 34 2.9
prf||2107260F ORF [Acinetobacter calcoaceticus] 34 2.9
gi|2688484 (AE001158) conserved hypothetical integral membr... 33 5.0
gi|2316062 (AF002651) NADH dehydrogenase 6 [Limulus polyphe... 33 5.0
gb|AAD40864.1|AF102710_1 (AF102710) cytochrome c oxidase su... 32 6.5
dbj|BAA16591| (D90899) iron(III) dicitrate transport system... 32 6.5
gnl|NCBI_MITO|ATP6_10512 ATP synthase F0 subunit 6 >gi|3121... 32 6.5
emb|CAA80467.1| (Z22813) NisK [Lactococcus lactis] 32 6.5
dbj|BAA79236.1| (AP000059) 220aa long hypothetical protein ... 32 8.5
gi|3168884 (AF068716) similar to E. coli thermoresistant gl... 32 8.5
gi|780431 (U18466) pM448R [African swine fever virus] >gi|1... 32 8.5
gnl|NCBI_MITO|ND6_10704 NADH dehydrogenase subunit 6 >gi|12... 32 8.5
gnl|NCBI_MITO|COX1_10587 cytochrome c oxidase subunit I >gi... 32 8.5
sp|P42707|NISK_LACLA NISIN BIOSYNTHESIS SENSOR PROTEIN NISK... 32 8.5
emb|CAB63796.1| (AL135751) putative transmembrane protein; battenin family
[Schizosaccharomyces pombe]
Length = 396
Score = 788 bits (2012), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MIKLRLTKDAKVGCCFLIFGLLNNLLYVIILSAALDLVGANVSKGVVLLSNIVPSLACKL 60
MIKLRLTKDAKVGCCFLIFGLLNNLLYVIILSAALDLVGANVSKGVVLLSNIVPSLACKL
Sbjct: 1 MIKLRLTKDAKVGCCFLIFGLLNNLLYVIILSAALDLVGANVSKGVVLLSNIVPSLACKL 60
Query: 61 SASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHL 120
SASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHL
Sbjct: 61 SASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHL 120
Query: 121 SSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVL 180
SSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVL
Sbjct: 121 SSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVL 180
Query: 181 PESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSE 240
PESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSE
Sbjct: 181 PESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSE 240
Query: 241 YTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSISFFTVPYLRTLAITQ 300
YTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSISFFTVPYLRTLAITQ
Sbjct: 241 YTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSISFFTVPYLRTLAITQ 300
Query: 301 FIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYHSLQTTESSQRELAISTVG 360
FIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYHSLQTTESSQRELAISTVG
Sbjct: 301 FIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYHSLQTTESSQRELAISTVG 360
Query: 361 SSDSSGIFLASLVSLFLEPSLCHFQADRGRDWCALT 396
SSDSSGIFLASLVSLFLEPSLCHFQADRGRDWCALT
Sbjct: 361 SSDSSGIFLASLVSLFLEPSLCHFQADRGRDWCALT 396
ref|NP_012476.1|YHC3| Yhc3p >gi|1352987|sp|P47040|BTN1_YEAST BTN1 PROTEIN
>gi|1078232|pir||S56831 probable membrane protein
YJL059w - yeast (Saccharomyces cerevisiae)
>gi|1008203|emb|CAA89350| (Z49334) ORF YJL059w
[Saccharomyces cerevisiae]
Length = 408
Score = 262 bits (662), Expect = 4e-69
Identities = 166/413 (40%), Positives = 236/413 (56%), Gaps = 34/413 (8%)
Query: 8 KDAKVGCCFLIFGLLNNLLYVIILSAALDLVGANVSKGVVLLSNIVPSLACKLSASILHV 67
K ++ C F +FGL+NN+LYV+ILSAA+D+VG + K +VLL++I PSLA KL S +
Sbjct: 4 KSHQIYCYFWLFGLINNVLYVVILSAAVDIVGPTLPKSLVLLADIFPSLAIKL-CSPFFI 62
Query: 68 HKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHLSSRYHSV 127
+ K++ RI + MS LGM +++ + +LG+S A+ISS FGE++FL L+ Y +
Sbjct: 63 DRIKYSYRIWSLITMSCLGMFLVSFKNLFVC-LLGISFASISSGFGEVTFLQLTHYYKQI 121
Query: 128 SLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVLPESESTS 187
SL WSSGTG AG+ G +SY+ +T+ F V+ TL++ S LP F + YF + ES T
Sbjct: 122 SLNGWSSGTGGAGIIGGASYMFLTSIFKVPVKLTLLVFSLLP-FAFLFYFKL--ESNDT- 177
Query: 188 PSINNNYTPIESID------LRAGHVSFNFVNS----------LKQTFIFMQPYLLSHMF 231
N Y ++ ID L V+F N+ + QT ++ + +M
Sbjct: 178 ---NLTYQSLQQIDEAEDDQLVPFPVAFTHTNASQSLYSTRQHILQTVKRLRRLVFPYMV 234
Query: 232 PQFLVYFSEYTINIGVAPTLLFP---PEKAG-----FSSFRDFYPTYQTVYQIGVFLSRS 283
P VY EY IN VAPTLLFP E++ F +RD Y TY T+YQ+GVF+SRS
Sbjct: 235 PLTTVYLFEYLINQAVAPTLLFPINGDERSKSMPFFFHKYRDIYVTYGTLYQLGVFISRS 294
Query: 284 SISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVY-H 342
+ L LA Q + L T+LQS Y+T S V+ LIF EG +GG YVN + +
Sbjct: 295 FGHLMRMRSLYILAFLQGVNLCITVLQSWFYVTHSPWAVMILIFYEGFLGGASYVNTFLN 354
Query: 343 SLQTTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLCHFQADRGRDWCAL 395
L+ + + E A+ V +DS G+FLA+L+ L LEP LC Q R WC +
Sbjct: 355 ILEQEDPDETEFAMGAVSIADSFGVFLAALLGLGLEPKLCRHQIADDRPWCRM 407
gi|3063665 (AF058447) Btn1p [Saccharomyces cerevisiae]
Length = 408
Score = 260 bits (658), Expect = 1e-68
Identities = 165/413 (39%), Positives = 236/413 (56%), Gaps = 34/413 (8%)
Query: 8 KDAKVGCCFLIFGLLNNLLYVIILSAALDLVGANVSKGVVLLSNIVPSLACKLSASILHV 67
K ++ C F +FGL+NN+LYV+ILSAA+D+VG + K +VLL++I PSLA KL S +
Sbjct: 4 KSHQIYCYFWLFGLINNVLYVVILSAAVDIVGPTLPKSLVLLADIFPSLAIKL-CSPFFI 62
Query: 68 HKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHLSSRYHSV 127
+ K++ RI + MS LGM +++ + +LG+S A+ISS FGE++FL L+ Y +
Sbjct: 63 DRIKYSYRIWSLITMSCLGMFLVSFKNLFVC-LLGISFASISSGFGEVTFLQLTHYYKQI 121
Query: 128 SLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVLPESESTS 187
SL WSSGTG AG+ G +SY+ +T+ F V+ TL++ S LP F + YF + ES T
Sbjct: 122 SLNGWSSGTGGAGIIGGASYMFLTSIFKVPVKLTLLVFSLLP-FAFLFYFKL--ESNDT- 177
Query: 188 PSINNNYTPIESID------LRAGHVSFNFVNS----------LKQTFIFMQPYLLSHMF 231
N + ++ ID L V+F N+ + QT ++ + +M
Sbjct: 178 ---NLTFQSLQQIDEAEDDQLVPFPVAFTHTNASQSLYSTRQHILQTVKRLRRLVFPYMV 234
Query: 232 PQFLVYFSEYTINIGVAPTLLFP---PEKAG-----FSSFRDFYPTYQTVYQIGVFLSRS 283
P VY EY IN VAPTLLFP E++ F +RD Y TY T+YQ+GVF+SRS
Sbjct: 235 PLTTVYLFEYLINQAVAPTLLFPINGDERSKSMPFFFHKYRDIYVTYGTLYQLGVFISRS 294
Query: 284 SISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVY-H 342
+ L LA Q + L T+LQS Y+T S V+ LIF EG +GG YVN + +
Sbjct: 295 FGHLMRMRSLYILAFLQGVNLCITVLQSWFYVTRSPWAVMILIFYEGFLGGASYVNTFLN 354
Query: 343 SLQTTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLCHFQADRGRDWCAL 395
L+ + + E A+ V +DS G+FLA+L+ L LEP LC Q R WC +
Sbjct: 355 ILEQEDPDETEFAMGAVSIADSFGVFLAALLGLGLEPKLCRHQIADDRPWCRM 407
gi|2388631 (U92811) CLN3 [Mus musculus]
Length = 438
Score = 177 bits (445), Expect = 1e-43
Identities = 131/402 (32%), Positives = 194/402 (47%), Gaps = 40/402 (9%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F I GL NN YV++LSAA D++ ++S V
Sbjct: 41 FWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHVEPGPTPTPHNSSSRFDCNSISTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAA 107
LL++I+P+L KL A L +H ++ R+ S +A+S SV + GV LA+
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLAS 159
Query: 108 ISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSF 167
ISS GE++FL L++ Y S + WSSGTG AGL G+ SYL +T S + TL+
Sbjct: 160 ISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQ-AGLSPQHTLLSMLG 218
Query: 168 LPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTFIFM 222
+P+ LL YF +L E P N P+ + ++ SL++ +
Sbjct: 219 IPVLLLASYFLLLTSPEPLDPGGENEAETAARQPLIGTETPESKPGASWDLSLQERWTVF 278
Query: 223 QPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSR 282
+ LL ++ P LVYF+EY IN G+ L F + S Y YQ +YQ GVF SR
Sbjct: 279 KG-LLWYIIPLVLVYFAEYFINQGLFELLFF---RNTSLSHAQQYRWYQMLYQAGVFASR 334
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYH 342
SS+ + + LA+ Q + L + L S + + +I EGL+GG YVN +H
Sbjct: 335 SSLQCCRIRFTWVLALLQCLNLALLLADVCLNFLPSIYLIFIIILYEGLLGGAAYVNTFH 394
Query: 343 SLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLCH 383
++ T RE A+ SD+ GI L+ +++L L LCH
Sbjct: 395 NIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCH 436
sp|Q29611|CLN3_CANFA CLN3 PROTEIN (BATTENIN) >gi|1478040 (L76281) CLN3 gene product
[Canis familiaris] >gi|2642359 (AF033661) CLN3 protein
[Canis familiaris]
Length = 438
Score = 177 bits (444), Expect = 2e-43
Identities = 134/405 (33%), Positives = 200/405 (49%), Gaps = 46/405 (11%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F + GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWLLGLCNNFSYVVMLSAAHDILSHQRASGNQSHVDPDPPPTAHNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVS 104
LL++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV
Sbjct: 101 LLADILPTLIIKLLAP-LGLHLLPYSPRVLVSGICAAGSFI---LVAFSHSVGTSLCGVV 156
Query: 105 LAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLII 164
LA+ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S + TL+
Sbjct: 157 LASISSGVGEVTFLSLTAFYPRAVISWWSSGTGGAGLMGALSYLGLTQ-AGLSPQHTLLS 215
Query: 165 SSFLPLFLLIMYFFVLPESESTSP-----SINNNYTPIESIDLRAGHVSFNFVNSLKQTF 219
+P +L YFF+L E P + + P+ + + SL++ +
Sbjct: 216 MLGIPALMLASYFFLLTSPEPQDPGGEEEAETSARQPLIDSETPESKPDSSSNLSLQERW 275
Query: 220 IFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVF 279
+ LL ++ P LVYF+EY IN G+ L F + Y YQ +YQ GVF
Sbjct: 276 TVFKG-LLWYIVPLVLVYFAEYFINQGLFELLFFRNTSLNHAQQ---YRWYQMLYQAGVF 331
Query: 280 LSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVN 339
+SRSS+ + + LA+ Q + L F ++ S + V +I EGL+GG YVN
Sbjct: 332 VSRSSLHCCRIRFTWVLALLQCLNLAFLLVDVWFSFLPSIYLVFLIILYEGLLGGAAYVN 391
Query: 340 VYHSLQTTESSQ-RELAISTVGSSDSSGIFLASLVSLFLEPSLCH 383
+H++ S Q RE A++ SD+ GI L+ L++L L LCH
Sbjct: 392 TFHNIALETSDQHREFAMAAACISDTLGISLSGLLALPLHDFLCH 436
sp|Q61124|CLN3_MOUSE CLN3 PROTEIN (BATTENIN) >gi|1736932 (U47106) homolog of human gene
underlying Batten disease (juvenile neuronal ceroid
lipofuscinosis) [Mus musculus]
Length = 438
Score = 176 bits (441), Expect = 4e-43
Identities = 131/402 (32%), Positives = 194/402 (47%), Gaps = 40/402 (9%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F I GL NN YV++LSAA D++ ++S V
Sbjct: 41 FWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHVEPGRTPTPHNSSSRFDCNSISTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAA 107
LL++I+P+L KL A L +H ++ R+ S +A+S SV + GV LA+
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLAS 159
Query: 108 ISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSF 167
ISS GE++FL L++ Y S + WSSGTG AGL G+ SYL +T S + TL+
Sbjct: 160 ISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQ-AGLSPQHTLLSMLG 218
Query: 168 LPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTFIFM 222
+P+ LL YF +L E P N P+ + ++ SL++ +
Sbjct: 219 IPVLLLASYFLLLTSPEPWDPGGENEAETAARQPLIGTETPESKPGASWDLSLQERWTVF 278
Query: 223 QPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSR 282
+ LL ++ P LVYF+EY IN G+ L F + S Y YQ +YQ GVF SR
Sbjct: 279 KG-LLWYIIPLVLVYFAEYFINQGLFELLFF---RNTSLSHAHEYRWYQMLYQAGVFASR 334
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYH 342
SS+ + + LA+ Q + L + L S + + +I EGL+GG YVN +H
Sbjct: 335 SSLQCCRIRFTWVLALLQCLNLALLLADVCLNFLPSIYLIFIIILHEGLLGGAAYVNTFH 394
Query: 343 SLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLCH 383
++ T RE A+ SD+ GI L+ +++L L LCH
Sbjct: 395 NIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCH 436
gi|1519717 (U68064) CLN3 [Mus musculus]
Length = 438
Score = 175 bits (439), Expect = 6e-43
Identities = 130/402 (32%), Positives = 194/402 (47%), Gaps = 40/402 (9%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F I GL NN YV++LSAA D++ ++S V
Sbjct: 41 FWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHVEPGPTPTPHNSSSRFDCNSISTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAA 107
LL++I+P+L KL A L ++ ++ R+ S +A+S SV + GV LA+
Sbjct: 101 LLADILPTLVIKLLAP-LGLYLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLAS 159
Query: 108 ISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSF 167
ISS GE++FL L++ Y S + WSSGTG AGL G+ SYL +T S + TL+
Sbjct: 160 ISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQ-AGLSPQHTLLSMLG 218
Query: 168 LPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTFIFM 222
+P+ LL YF +L E P N P+ + ++ SL++ +
Sbjct: 219 IPVLLLASYFLLLTSPEPLDPGGENEAETAARQPLIGTETPESKPGASWDLSLQERWTVF 278
Query: 223 QPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSR 282
+ LL ++ P LVYF+EY IN G+ L F + S Y YQ +YQ GVF SR
Sbjct: 279 KG-LLWYIIPLVLVYFAEYFINQGLFELLFF---RNTSLSHAQQYRWYQMLYQAGVFASR 334
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYH 342
SS+ + + LA+ Q + L + L S + + +I EGL+GG YVN +H
Sbjct: 335 SSLQCCRIRFTWVLALLQCLNLALLLADVCLNFLPSIYLIFIIILYEGLLGGAAYVNTFH 394
Query: 343 SLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLCH 383
++ T RE A+ SD+ GI L+ +++L L LCH
Sbjct: 395 NIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCH 436
ref|NP_000077.1|PCLN3| ceroid-lipofuscinosis, neuronal 3, juvenile (Batten,
Spielmeyer-Vogt disease)
>gi|2498243|sp|Q13286|CLN3_HUMAN CLN3 PROTEIN (BATTENIN)
(BATTEN'S DISEASE PROTEIN) >gi|1362757|pir||A57219
Batten disease-related protein CLN3 - human >gi|1039423
(U32680) CLN3 protein [Homo sapiens]
>gi|1834482|emb|CAA68148| (X99832) CLN3 protein [Homo
sapiens] >gi|2947055|gb|AAC05337.1| (AC002425) CLN3
[Homo sapiens] >gi|3337387|gb|AAC27430.1| (AC002544) CLN
[Homo sapiens] >gi|4102729 (AF015593) CLN3 protein [Homo
sapiens] >gi|5730394|gb|AAD48543.1|AF078169_1 (AF078169)
CLN3 protein [Homo sapiens]
>gi|5801831|gb|AAD51478.1|AF077956_1 (AF077956) CLN3
protein [Homo sapiens]
>gi|5801833|gb|AAD51479.1|AF077957_1 (AF077957) CLN3
protein [Homo sapiens]
>gi|5801835|gb|AAD51480.1|AF077958_1 (AF077958) CLN3
protein [Homo sapiens]
>gi|5801837|gb|AAD51481.1|AF077959_1 (AF077959) CLN3
protein [Homo sapiens]
>gi|5801841|gb|AAD51483.1|AF077961_1 (AF077961) CLN3
protein [Homo sapiens]
>gi|5801843|gb|AAD51484.1|AF077962_1 (AF077962) CLN3
protein [Homo sapiens]
>gi|5801861|gb|AAD51493.1|AF077971_1 (AF077971) CLN3
protein [Homo sapiens] >gi|1583579|prf||2121264A CLN3
gene [Homo sapiens]
Length = 438
Score = 169 bits (425), Expect = 3e-41
Identities = 131/404 (32%), Positives = 194/404 (47%), Gaps = 46/404 (11%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F + GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVS 104
LL++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVGTSLCGVV 156
Query: 105 LAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLII 164
A+ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S + TL+
Sbjct: 157 FASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQ-AGLSPQQTLLS 215
Query: 165 SSFLPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTF 219
+P LL YF +L E+ P P+ + + SL++ +
Sbjct: 216 MLGIPALLLASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERW 275
Query: 220 IFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVF 279
+ LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ GVF
Sbjct: 276 TVFKG-LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVF 331
Query: 280 LSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVN 339
SRSS+ + + LA+ Q + L+F + S + V +I EGL+GG YVN
Sbjct: 332 ASRSSLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVN 391
Query: 340 VYHSLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
+H++ T RE A++ SD+ GI L+ L++L L LC
Sbjct: 392 TFHNIALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFLC 435
gb|AAD51488.1|AF077966_1 (AF077966) CLN3 protein [Homo sapiens]
Length = 438
Score = 168 bits (421), Expect = 8e-41
Identities = 130/404 (32%), Positives = 194/404 (47%), Gaps = 46/404 (11%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F + GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVS 104
LL++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVGTSLCGVV 156
Query: 105 LAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLII 164
A+ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S + TL+
Sbjct: 157 FASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQ-AGLSPQQTLLS 215
Query: 165 SSFLPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTF 219
+P LL YF +L E+ P P+ + + SL++ +
Sbjct: 216 MLGIPALLLASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERW 275
Query: 220 IFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVF 279
+ LL ++ P +VYF++Y IN G+ L F S Y YQ +YQ GVF
Sbjct: 276 TVFKG-LLWYIVPLVVVYFAKYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVF 331
Query: 280 LSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVN 339
SRSS+ + + LA+ Q + L+F + S + V +I EGL+GG YVN
Sbjct: 332 ASRSSLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVN 391
Query: 340 VYHSLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
+H++ T RE A++ SD+ GI L+ L++L L LC
Sbjct: 392 TFHNIALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFLC 435
gi|1703588 (U80439) C01G8.2 [Caenorhabditis elegans]
Length = 435
Score = 168 bits (420), Expect = 1e-40
Identities = 131/419 (31%), Positives = 202/419 (47%), Gaps = 57/419 (13%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGAN-------------------VSKGVVLLSNIVPSL 56
F + GL NN YV++LSAA D++ + +S G VLL++I+P+L
Sbjct: 18 FWLLGLCNNFAYVVMLSAAKDILEKDAKHIEKPCREHVTTRECQMMSTGSVLLADIIPAL 77
Query: 57 ACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEIS 116
K++A + +H+ F R V + + S S + GV LA+ S GEIS
Sbjct: 78 LIKITAPMF-IHRVPFGIRHSIVVLLQASSFLIVGISDSTALALFGVVLASFGSGLGEIS 136
Query: 117 FLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMT--TWFNFSVRSTLIISSFLPLFLLI 174
+L LSS Y S + WSSGTG AGL GAS+Y ++T S + T+ I LP +
Sbjct: 137 YLALSSNYPSTVVASWSSGTGGAGLIGASAYALLTDSKLLAISPKHTMFIMLTLPALFSV 196
Query: 175 MYFFVLPESEST------SPS---INNNYTPIESIDLRAGHV---------------SFN 210
Y+ +L S PS + ++ P + D+R V S +
Sbjct: 197 SYWSILKIPHSVQRAHFLQPSTWLVTGDFIPAD--DMRREEVEEEEGLLGIREDRENSVD 254
Query: 211 FVNSLKQTFIFMQPY--LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYP 268
+ +QT ++ LL M P VY +EY IN G+ L F S Y
Sbjct: 255 VTSRRRQTSTTLERVLPLLKFMIPLISVYLAEYYINQGLLELLEFDCSHGFSMSSESQYR 314
Query: 269 TYQTVYQIGVFLSRSSISFFTVP--YLRTLAITQ-FIILLFTILQSALYLTSSYHFVLFL 325
+Q YQ+GVF+SRSS ++ T+P YL++LA+ Q F FTI +A+Y + + FL
Sbjct: 315 WFQVTYQLGVFISRSSSNYVTIPTQYLKSLAVLQIFNAGFFTI--TAIYSFLPHILIAFL 372
Query: 326 IFV-EGLIGGTVYVNVYHSL-QTTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
+ + EGL+GG YVN + ++ + + RE ++ V SD+ GI A +++ + +C
Sbjct: 373 VILFEGLLGGASYVNTFRAVHKEIPADSREFSMGVVSISDTIGIVFAGFLAMPVHNRIC 431
gi|2388633 (U92812) CLN3 [Oryctolagus cuniculus]
Length = 419
Score = 162 bits (405), Expect = 6e-39
Identities = 124/385 (32%), Positives = 185/385 (47%), Gaps = 40/385 (10%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F I GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWILGLCNNFSYVVMLSAAHDILSHQGSPGNQSHVDPGPVPSPYNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAA 107
LL++I+P+L KL A L +H ++ R+ S +A+S SV + GV LA+
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLISGVCSAGSFILVAFSGSVGISLCGVVLAS 159
Query: 108 ISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSF 167
ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S ++TL+
Sbjct: 160 ISSGLGEVTFLSLTAIYPRAVISWWSSGTGGAGLLGALSYLGLTQ-AGLSPQNTLLSMLG 218
Query: 168 LPLFLLIMYFFVLPESESTSPSINN-----NYTPIESIDLRAGHVSFNFVNSLKQTFIFM 222
+P LL YF +L ES P + P+ S + ++ S ++ +
Sbjct: 219 IPALLLASYFLLLTTPESQDPGGGDEAETATRQPLLSSEAPESRPDSSWNLSFQEKWTVF 278
Query: 223 QPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSR 282
+ LL ++ P LVYF+EY IN G+ L F + + Y YQ +YQ GVF+SR
Sbjct: 279 KG-LLCYIIPLVLVYFAEYFINQGLFELLFF---RNTSLTHAQQYRWYQMLYQAGVFISR 334
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYH 342
SS+ + + LA+ Q + + + L S + V +I EGL+GG YVN +H
Sbjct: 335 SSLRCCRIRFTWALALLQCLNMAVLLADIWLSFLPSIYLVFGVILYEGLLGGAAYVNTFH 394
Query: 343 SLQ-TTESSQRELAISTVGSSDSSG 366
++ T RE A++ SD+ G
Sbjct: 395 NIALETSDKHREFAMAAACISDTLG 419
emb|CAB01140.1| (Z77656) predicted using Genefinder; Similarity to Human CLN3
protein (TR:G1039423) [Caenorhabditis elegans]
Length = 424
Score = 160 bits (400), Expect = 2e-38
Identities = 120/414 (28%), Positives = 196/414 (46%), Gaps = 48/414 (11%)
Query: 16 FLIFGLLNNLLYVIILSAALDLV----GAN--------------------VSKGVVLLSN 51
F + GL NN YVI+LSAA D++ G N +S G VLL++
Sbjct: 13 FWLLGLCNNYGYVIMLSAAEDILDDQKGTNSSSTNSSTCETHLDSRHCQSISTGAVLLAD 72
Query: 52 IVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSS 111
+P+L + + +H+F F R + +A+S ++ + GV +A++
Sbjct: 73 NLPALVVQTTFPFF-MHRFPFGFRAFLVFLLQASSYFVVAYSKNIAMSLAGVCMASLGQG 131
Query: 112 FGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLF 171
GEI+FL +++ Y ++ WSSGTG AGL G+ SY +T S +TL++ F+P+
Sbjct: 132 IGEITFLAMAAHYIPETIASWSSGTGGAGLIGSFSYAFITQ-AGLSPSNTLLVQLFIPVV 190
Query: 172 LLIMYFFVL--------PESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQ 223
YFF+L P ++ I NY + A + +N+ K +
Sbjct: 191 FAGAYFFLLTIPPTVYSPTIHPSTWIIPKNY---DKDVFEAAEARGDVLNTKKVPQRELG 247
Query: 224 PY--------LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQ 275
P LL M P VY +EY IN G+ ++F + Y YQ +YQ
Sbjct: 248 PLERIKLIGPLLYLMVPLATVYTAEYMINQGLTELIIFNCSQGLSLPLSSQYRWYQVLYQ 307
Query: 276 IGVFLSRSSISFFTVP--YLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIG 333
+GVF+SRSS+ FF +P + L I Q + ++F ++ + T + + LI EGL+G
Sbjct: 308 LGVFISRSSVKFFEMPLWLIWCLPILQCVNMIFFFFEAVYWFTPTIIIIFVLIVFEGLLG 367
Query: 334 GTVYVNVYHSL-QTTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLCHFQA 386
G+ YVN Y+ + + RE ++S +S G +A+ +S+ L +C +A
Sbjct: 368 GSAYVNTYNKIHKKVNPDVREYSLSAASMGNSLGTNIAAFLSIPLYNWVCTMKA 421
gb|AAD51494.1|AF077972_1 (AF077972) CLN3 protein [Homo sapiens]
Length = 421
Score = 146 bits (366), Expect = 2e-34
Identities = 120/404 (29%), Positives = 185/404 (45%), Gaps = 63/404 (15%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F + GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVS 104
LL++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVGTSLCGVV 156
Query: 105 LAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLII 164
A+ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S + TL+
Sbjct: 157 FASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQ-AGLSPQQTLLS 215
Query: 165 SSFLPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTF 219
+P LL YF +L E+ P P+ + + SL++ +
Sbjct: 216 MLGIPALLLASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERW 275
Query: 220 IFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVF 279
+ +++ L++F ++ S Y YQ +YQ GVF
Sbjct: 276 TVFKVRMMAGF---ELLFFWNTSL------------------SHAQQYRWYQMLYQAGVF 314
Query: 280 LSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVN 339
SRSS+ + + LA+ Q + L+F + S + V +I EGL+GG YVN
Sbjct: 315 ASRSSLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVN 374
Query: 340 VYHSLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
+H++ T RE A++ SD+ GI L+ L++L L LC
Sbjct: 375 TFHNIALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFLC 418
gb|AAD51482.1|AF077960_1 (AF077960) CLN3 protein [Homo sapiens]
Length = 390
Score = 122 bits (302), Expect = 7e-27
Identities = 120/400 (30%), Positives = 173/400 (43%), Gaps = 86/400 (21%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F + GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVS 104
LL++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVGTSLCGVV 156
Query: 105 LAAISSSFGEISFLHLSSRYHSVSLPCWS-SGTGLAGLFGASSYLVMTTWFNFSVRSTLI 163
A+ISS GE++FL L++ Y S L S G A S + R LI
Sbjct: 157 FASISSGLGEVTFLSLTAFYPSYFLLLTSPEAQDPGGEEEAES----------AARQPLI 206
Query: 164 ISSFLPLFLLIMYFFVLPESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQ 223
+ PES+ S S S+ LR F
Sbjct: 207 RTE-------------APESKPGSSS---------SLSLRERWTVFKG------------ 232
Query: 224 PYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRS 283
LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ GVF SRS
Sbjct: 233 --LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVFASRS 287
Query: 284 SISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYHS 343
S+ + + LA+ Q + L+F + S + V +I EGL+GG YVN +H+
Sbjct: 288 SLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHN 347
Query: 344 LQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
+ T RE A++ SD+ GI L+ L++L L LC
Sbjct: 348 IALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFLC 387
gi|4102731 (AF015594) CLN3 protein [Homo sapiens]
Length = 320
Score = 120 bits (299), Expect = 2e-26
Identities = 101/316 (31%), Positives = 148/316 (45%), Gaps = 45/316 (14%)
Query: 18 IFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVVLL 49
+ GL NN YV++LSAA D++ +VS VLL
Sbjct: 14 LLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAVLL 73
Query: 50 SNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVSLA 106
++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV A
Sbjct: 74 ADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVGTSLCGVVFA 129
Query: 107 AISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISS 166
+ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S + TL+
Sbjct: 130 SISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQ-AGLSPQQTLLSML 188
Query: 167 FLPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTFIF 221
+P LL YF +L E+ P P+ + + SL++ +
Sbjct: 189 GIPALLLASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERWTV 248
Query: 222 MQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLS 281
+ LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ GVF S
Sbjct: 249 FKG-LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVFAS 304
Query: 282 RSSISFFTVPYLRTLA 297
RSS+ + + LA
Sbjct: 305 RSSLRCCRIRFTWALA 320
gi|4102733 (AF015595) CLN3 protein [Homo sapiens]
Length = 336
Score = 113 bits (281), Expect = 2e-24
Identities = 108/347 (31%), Positives = 156/347 (44%), Gaps = 58/347 (16%)
Query: 41 NVSKGVVLLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVP 97
+VS VLL++I+P+L KL A L +H ++ R+ G C S + +A+S SV
Sbjct: 40 SVSTAAVLLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVG 95
Query: 98 SKMLGVSLAAISSSFGEISFLHLSSRYHSVSLPCWS-SGTGLAGLFGASSYLVMTTWFNF 156
+ + GV A+ISS GE++FL L++ Y S L S G A S
Sbjct: 96 TSLCGVVFASISSGLGEVTFLSLTAFYPSYFLLLTSPEAQDPGGEEEAES---------- 145
Query: 157 SVRSTLIISSFLPLFLLIMYFFVLPESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLK 216
+ R LI + PES+ S S S+ LR F
Sbjct: 146 AARQPLIRTE-------------APESKPGSSS---------SLSLRERWTVFKG----- 178
Query: 217 QTFIFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQI 276
LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ
Sbjct: 179 ---------LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQA 226
Query: 277 GVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTV 336
GVF SRSS+ + + LA+ Q + L+F + S + V +I EGL+GG
Sbjct: 227 GVFASRSSLRCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAA 286
Query: 337 YVNVYHSLQ-TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
YVN +H++ T RE A++ SD+ GI L+ L++L L LC
Sbjct: 287 YVNTFHNIALETSDEHREFAMAATCISDTLGISLSGLLALPLHDFLC 333
gb|AAD51485.1|AF077963_1 (AF077963) CLN3 protein [Homo sapiens]
Length = 321
Score = 107 bits (264), Expect = 2e-22
Identities = 87/274 (31%), Positives = 130/274 (46%), Gaps = 42/274 (15%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGA----------------------------NVSKGVV 47
F + GL NN YV++LSAA D++ +VS V
Sbjct: 41 FWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAV 100
Query: 48 LLSNIVPSLACKLSASILHVHKFKFAKRI---GFCVFMSILGMQWIAWSSSVPSKMLGVS 104
LL++I+P+L KL A L +H ++ R+ G C S + +A+S SV + + GV
Sbjct: 101 LLADILPTLVIKLLAP-LGLHLLPYSPRVLVSGICAAGSFV---LVAFSHSVGTSLCGVV 156
Query: 105 LAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLII 164
A+ISS GE++FL L++ Y + WSSGTG AGL GA SYL +T S + TL+
Sbjct: 157 FASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQ-AGLSPQQTLLS 215
Query: 165 SSFLPLFLLIMYFFVLPESESTSPSINNN-----YTPIESIDLRAGHVSFNFVNSLKQTF 219
+P LL YF +L E+ P P+ + + SL++ +
Sbjct: 216 MLGIPALLLASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERW 275
Query: 220 IFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLF 253
+ LL ++ P +VYF+EY IN G+ L F
Sbjct: 276 TVFKG-LLWYIVPLVVVYFAEYFINQGLFELLFF 308
gi|3329658 (AF078788) similar to Batten disease-related protein CLN3
[Caenorhabditis elegans]
Length = 375
Score = 92.4 bits (226), Expect = 6e-18
Identities = 103/400 (25%), Positives = 152/400 (37%), Gaps = 88/400 (22%)
Query: 16 FLIFGLLNNLLYVIILSAALDLVGANVSK----------------------GVVLLSNIV 53
F + GL NN YVI+LSAA D++ K VLLS+ +
Sbjct: 25 FSLIGLCNNYGYVIMLSAAEDILSEQHGKVKSNATDLCLPAITKRECKPPVAEVLLSDNL 84
Query: 54 PSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFG 113
PSL KL+ + +F F R+ + +A+S S+P +SLA +
Sbjct: 85 PSLIVKLTFPFF-MDRFPFGFRVAIVCLLQATSYFVVAFSVSIP-----MSLAGVVF--- 135
Query: 114 EISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLL 173
L G G ++L ++ +
Sbjct: 136 ----------------------VSLGGGLGEITFLGLSAHYQ------------------ 155
Query: 174 IMYFFVLPESEST-SPSIN-------NNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPY 225
YF +L + ES SP+++ Y + R + LK + P
Sbjct: 156 -RYFILLKKPESVYSPTLDPKSWIVPKGYDDFIVSEHRVPQRELGPSDRLK----LILP- 209
Query: 226 LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSI 285
+L M P +VY EY IN G+ ++F S Y YQ +YQ GVF+SRSSI
Sbjct: 210 MLHLMIPLAIVYVGEYMINQGMTQQIVFDCAHGFNLSLHSQYRWYQVLYQFGVFVSRSSI 269
Query: 286 SFFTVP--YLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYHS 343
+P L L Q +LF + + + LI EGL GG+ YVN +H
Sbjct: 270 RLVELPMWMLYLLPFLQLTNMLFFFFDALYWFVPQIAIIFALIIFEGLFGGSSYVNTFHK 329
Query: 344 LQT-TESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
+ E RE +S DS G+ A+ VS+ L +C
Sbjct: 330 IHNKVEPDVREYCLSAASMGDSIGVNFAAGVSIPLHYWMC 369
gi|4102739 (AF015598) CLN3 protein [Homo sapiens]
Length = 339
Score = 90.5 bits (221), Expect = 2e-17
Identities = 57/158 (36%), Positives = 82/158 (51%), Gaps = 4/158 (2%)
Query: 226 LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSI 285
LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ GVF SRSS+
Sbjct: 182 LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVFASRSSL 238
Query: 286 SFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGLIGGTVYVNVYHSLQ 345
+ + LA+ Q + L+F + S + V +I EGL+GG YVN +H++
Sbjct: 239 RCCRIRFTWALALLQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHNIA 298
Query: 346 -TTESSQRELAISTVGSSDSSGIFLASLVSLFLEPSLC 382
T RE A++ SD+ GI L+ L++L L LC
Sbjct: 299 LETSDEHREFAMAATCISDTLGISLSGLLALPLHDFLC 336
gi|4102735 (AF015596) CLN3 protein [Homo sapiens]
Length = 85
Score = 63.6 bits (152), Expect = 3e-09
Identities = 37/84 (44%), Positives = 51/84 (60%), Gaps = 1/84 (1%)
Query: 90 IAWSSSVPSKMLGVSLAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLV 149
+A+S SV + + GV A+ISS GE++FL L++ Y + WSSGTG AGL GA SYL
Sbjct: 2 VAFSHSVGTSLCGVVFASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLG 61
Query: 150 MTTWFNFSVRSTLIISSFLPLFLL 173
+T S + TL+ +P LL
Sbjct: 62 LTQ-AGLSPQQTLLSMLGIPALLL 84
gb|AAD51487.1|AF077965_1 (AF077965) CLN3 protein [Homo sapiens]
Length = 253
Score = 45.3 bits (105), Expect = 9e-04
Identities = 29/75 (38%), Positives = 39/75 (51%), Gaps = 3/75 (4%)
Query: 226 LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSI 285
LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ GVF SRSS+
Sbjct: 171 LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVFASRSSL 227
Query: 286 SFFTVPYLRTLAITQ 300
+ + LA+ Q
Sbjct: 228 RCCRIRFTWALALLQ 242
gi|1478042 (L76282) CLN3 gene product [Canis familiaris]
Length = 67
Score = 44.1 bits (102), Expect = 0.002
Identities = 26/60 (43%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
Query: 226 LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSI 285
LL ++ P LVYF+EY IN G+ L F + Y YQ +YQ GVF+SRSS+
Sbjct: 6 LLWYIVPLVLVYFAEYFINQGLFELLFFRNTSLNHA---QQYRWYQMLYQAGVFVSRSSL 62
gi|4102743 (AF015600) CLN3 protein [Homo sapiens]
Length = 209
Score = 42.2 bits (97), Expect = 0.008
Identities = 26/60 (43%), Positives = 33/60 (54%), Gaps = 3/60 (5%)
Query: 226 LLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSI 285
LL ++ P +VYF+EY IN G+ L F S Y YQ +YQ GVF SRSS+
Sbjct: 153 LLWYIVPLVVVYFAEYFINQGLFELLFFWNTSL---SHAQQYRWYQMLYQAGVFASRSSL 209
emb|CAA04021| (AJ000346) NapC protein [Enterococcus hirae]
Length = 400
Score = 39.5 bits (90), Expect = 0.051
Identities = 67/330 (20%), Positives = 139/330 (41%), Gaps = 41/330 (12%)
Query: 32 SAALDLVGANVSKGVVLLSNIVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIA 91
+ + L+ A + + L + ++ +L+ + I+ + F IG+ +F G WI
Sbjct: 46 ATTVTLLSAIYAFSMFLAAPMLGALSDRFGRKIILISSL-FGSAIGYYLF-GFGGALWIL 103
Query: 92 WSSSVPSKMLGVSLAAISSSFGEISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMT 151
+ + + G ++AI + F +++ + ++Y W S T G+ A+ L+
Sbjct: 104 FLGRIIEGLTGGEISAILAYFADLTPIESRTKYFG-----WISAT--VGIGTAAGPLIGG 156
Query: 152 TWFNFSVRSTLIISSFLPLFLLIMYFFVLPES----ESTSPSINNNYTPIESIDLRAGHV 207
+ L ++SFL L + +F +PES E T P + + L
Sbjct: 157 FLAQYGPAIPLYVASFLSLSNAVYGYFFMPESLTKRERTRNLSLQQINPFKQLQL----- 211
Query: 208 SFNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFY 267
F F S+K ++ + +L+ F F++++I+ T P GF
Sbjct: 212 VFTF-RSVK--WLLITGFLIWLPNGSFQAIFAQFSID-----TFHLSPIIIGF------- 256
Query: 268 PTYQTVYQIGVF----LSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVL 323
T+ + + +F + + F+ + T+ IT +I I+ SA Y S F++
Sbjct: 257 -TFSLIGIMDIFAQLLIMPILLKFWRENQIITMGITSEMIGYSVIILSAFY-GSIPCFII 314
Query: 324 FLIFVEGLIGGTVYVNVYHSLQTTESSQRE 353
++F +G ++ Y+ L +T +S+ +
Sbjct: 315 GMVFFG--LGDAIFSPSYNGLISTYASKED 342
gb|AAD30608.1|AC007369_18 (AC007369) Sugar transporter [Arabidopsis thaliana]
Length = 734
Score = 36.4 bits (82), Expect = 0.44
Identities = 43/191 (22%), Positives = 88/191 (45%), Gaps = 22/191 (11%)
Query: 10 AKVGCCFLIFGLLNNLLYVIILSAALDLVGANVSKGVVL--LSNIVPSLACKLSASILHV 67
+ + FLI GL LL + + A+ L+ + + ++L + ++ SL + + ++H+
Sbjct: 552 SSISASFLISGL-TTLLMLPAIVVAMRLMDVSGRRSLLLWTIPVLIVSLVVLVISELIHI 610
Query: 68 HKFKFAKR------IGFCVFMSILG-MQWIAWSSSVPSKMLGVSLAAISSSF--GEISFL 118
K A + FC F+ G + I S P+++ G+ +A + F G+I
Sbjct: 611 SKVVNAALSTGCVVLYFCFFVMGYGPIPNILCSEIFPTRVRGLCIAICAMVFWIGDIIVT 670
Query: 119 HLSSRYHSVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFF 178
+ SLP S GL G+F + + + +W V + + +PL ++ YF
Sbjct: 671 Y--------SLPVLLSSIGLVGVFSIYAAVCVISW--IFVYMKVPETKGMPLEVITDYFA 720
Query: 179 VLPESESTSPS 189
++++++PS
Sbjct: 721 FGAQAQASAPS 731
emb|CAB07312.1| (Z92825) predicted using Genefinder [Caenorhabditis elegans]
Length = 467
Score = 35.2 bits (79), Expect = 0.98
Identities = 65/325 (20%), Positives = 125/325 (38%), Gaps = 64/325 (19%)
Query: 100 MLGVSLAAISSS----FGEISFLHLSSRYH-SVSLPCWSS-------GTGLAGLFGASSY 147
++G S+AA + F +I+ R+ S ++ C +S GT L + +S+
Sbjct: 124 IIGTSIAAAAQMYFVVFSKIAESWFYPRHRASANVACSNSLELGVVLGTVLPSIIVPASF 183
Query: 148 L--VMTTWFNFSVRSTLIISSFLPLFLLIMYFFVLPESE--STSPSINNNYTPIESIDLR 203
++++W F + S + + +PLFLL FVL T PS ++ +
Sbjct: 184 TKDIVSSWTFFLLNSIIAVVCIIPLFLL----FVLCRRSVPKTPPSASSQHE-------S 232
Query: 204 AGHVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSF 263
+G V+ LK QFL+ Y+IN +A L++ + +
Sbjct: 233 SGPVTSGIFKCLKDR--------------QFLIQIFVYSINFAIANGLIYTSNAINYRGY 278
Query: 264 R-DFYP-------TYQTVYQIGVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYL 315
YP + Y +GV R+ + +AI +++ +L LYL
Sbjct: 279 NLKGYPIAIATMVCMFSAYFVGVIADRTR-------KFKLIAIINALVVAVCVLVLRLYL 331
Query: 316 TSSYHFVLFLIFVEGLIGGTVYVNVYHS-------LQTTESSQRELAISTVGSSDSSGIF 368
+Y + V L+ + H+ ++TT Q ++ + + + +F
Sbjct: 332 IKTYTGWYDSVIVCTLLSIIMSCCAIHTPIGNEMGVETTYPVQESISTGVLNTFGQAWLF 391
Query: 369 LASLVSLFLEPSLCHFQADR-GRDW 392
+ L+ S ++ +R G W
Sbjct: 392 CLYFIMYSLQESNWVYKNNRKGGSW 416
sp|Q36428|NU5M_LOCMI NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5
Length = 572
Score = 34.8 bits (78), Expect = 1.3
Identities = 57/256 (22%), Positives = 103/256 (39%), Gaps = 22/256 (8%)
Query: 66 HVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHLSSRYH 125
++H K R V M IL M ++ S ++ S +LG + S I + ++ S Y+
Sbjct: 75 YMHNEKNINRFIMIVLMFILSMAFLIISPNLISILLGWDGLGLVSYCLVIYYQNVKS-YN 133
Query: 126 SVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSF-LPLFLLIMYFFVLPES- 183
+ L S+ G + + S+++ +N+ I SF + + L++ + +S
Sbjct: 134 AGMLTALSNRIGDVAILISISWMLNFGSWNYIYYYYFISDSFEMKIITLLIILAAMTKSA 193
Query: 184 ----ESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVY-F 238
S P+ TP+ ++ V+S T + YLL P +VY F
Sbjct: 194 QIPFSSWLPAAMAAPTPVSAL-----------VHS--STLVTAGVYLLIRFNPMLMVYDF 240
Query: 239 SEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSISFFTVPYLRTLAI 298
Y + IG T+ A F T+ Q+G+ +S S+ + + + L
Sbjct: 241 GWYILFIGCL-TMFMSGLGANFEFDLKKIIALSTLSQLGLMMSILSMGYSDLAFFHLLTH 299
Query: 299 TQFIILLFTILQSALY 314
F LLF S ++
Sbjct: 300 ALFKALLFMCAGSMIH 315
gnl|NCBI_MITO|ND5_10712 NADH dehydrogenase subunit 5 >gi|1185126|emb|CAA56538| (X80245) ND5
[Locusta migratoria]
Length = 572
Score = 34.8 bits (78), Expect = 1.3
Identities = 57/256 (22%), Positives = 103/256 (39%), Gaps = 22/256 (8%)
Query: 66 HVHKFKFAKRIGFCVFMSILGMQWIAWSSSVPSKMLGVSLAAISSSFGEISFLHLSSRYH 125
++H K R V M IL M ++ S ++ S +LG + S I + ++ S Y+
Sbjct: 75 YMHNEKNINRFIMIVLMFILSMAFLIISPNLISILLGWDGLGLVSYCLVIYYQNVKS-YN 133
Query: 126 SVSLPCWSSGTGLAGLFGASSYLVMTTWFNFSVRSTLIISSF-LPLFLLIMYFFVLPES- 183
+ L S+ G + + S+++ +N+ I SF + + L++ + +S
Sbjct: 134 AGMLTALSNRIGDVAILISISWMLNFGSWNYIYYYYFISDSFEMKIITLLIILAAMTKSA 193
Query: 184 ----ESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVY-F 238
S P+ TP+ ++ V+S T + YLL P +VY F
Sbjct: 194 QIPFSSWLPAAMAAPTPVSAL-----------VHS--STLVTAGVYLLIRFNPMLMVYDF 240
Query: 239 SEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSISFFTVPYLRTLAI 298
Y + IG T+ A F T+ Q+G+ +S S+ + + + L
Sbjct: 241 GWYILFIGCL-TMFMSGLGANFEFDLKKIIALSTLSQLGLMMSILSMGYSDLAFFHLLTH 299
Query: 299 TQFIILLFTILQSALY 314
F LLF S ++
Sbjct: 300 ALFKALLFMCAGSMIH 315
gnl|NCBI_MITO|ND6_10015 NADH dehydrogenase subunit 6 >gi|128815|sp|P07709|NU6M_DROYA
NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6
>gi|85261|pir||B30020 hypothetical protein 6 - fruit fly
(Drosophila yakuba) mitochondrion (SGC4)
>gi|529259|emb|CAA26995| (X03240) URF6 (aa 1-174)
[Drosophila yakuba]
Length = 174
Score = 34.4 bits (77), Expect = 1.7
Identities = 21/57 (36%), Positives = 32/57 (55%), Gaps = 1/57 (1%)
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSS-YHFVLFLIFVEGLIGGTVYV 338
+SI FF + + L +T I +F L S L S Y ++LFLIF+ G++ +YV
Sbjct: 13 TSIIFFNMIHPLALGLTLLIQTIFVCLLSGLMTKSFWYSYILFLIFLGGMLVLFIYV 69
sp|Q43975|PCAK_ACICA 4-HYDROXYBENZOATE TRANSPORTER >gi|3172116 (L05770) putative
transport protein [Acinetobacter sp. ADP1]
Length = 457
Score = 33.6 bits (75), Expect = 2.9
Identities = 29/122 (23%), Positives = 56/122 (45%), Gaps = 13/122 (10%)
Query: 71 KFAKRIGFCVFMSILGMQWIA--WSSSVPSKML-----GVSLAAISSSFGEISFLHLSSR 123
+F ++I + M + G +A +S+++ S ++ G+ L A + + + +R
Sbjct: 97 RFGRKIVLSMSMLVFGGFTLACAYSTNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPAR 156
Query: 124 YHSVSLPCWSSGTGLAGLFGA--SSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVLP 181
S+ + C G L G SS+L+ F S ++ + PL L+++ F LP
Sbjct: 157 IRSLLVTCMFCGYNLGMAIGGFISSWLIPA----FGWHSLFLLGGWAPLILMLLVIFFLP 212
Query: 182 ES 183
ES
Sbjct: 213 ES 214
emb|CAA74938| (Y14599) hypothetical protein [Staphylococcus xylosus]
Length = 209
Score = 33.6 bits (75), Expect = 2.9
Identities = 41/149 (27%), Positives = 69/149 (45%), Gaps = 27/149 (18%)
Query: 88 QWIAWSSSVPS----------KMLGVSLAAISSSFGEISFLHLSSRYHSVSLPCWSSGTG 137
+W+ + S++PS G+ L I FG IS ++ ++ + +
Sbjct: 61 KWMYYISTLPSGRSAYVNSYFSFYGI-LTLIGFIFGVISVSLITQDFNVILMSI------ 113
Query: 138 LAGLFGASSYLVM-TTWFNFSVRST---LIISSFLPLFLLIMYFFVLPESE---STSPSI 190
L G+ GA +Y +M F F ++ LI +SF+ LFL + FF + SE S S +I
Sbjct: 114 LVGIGGAGTYAMMFPLTFKFGPENSNVILISTSFIVLFLFFIVFFGMNLSEVAVSGSDAI 173
Query: 191 N-NNYTPIESIDLRAGHVSF--NFVNSLK 216
N N + + G ++F ++V SLK
Sbjct: 174 NLTNSIVVVGVYALVGIIAFVLSYVTSLK 202
emb|CAB16543.1| (Z99286) Y7A9C.3 [Caenorhabditis elegans]
Length = 489
Score = 33.6 bits (75), Expect = 2.9
Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 8/94 (8%)
Query: 233 QFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVYQIGVFLSRSSISFFTVPY 292
Q +Y+ T+ + TLLFP + FY + + + V L F +
Sbjct: 153 QKYIYWQTLTVFV-CKSTLLFP-------TVSHFYEMVKFTFYLLVLLILCIPLLFVATH 204
Query: 293 LRTLAITQFIILLFTILQSALYLTSSYHFVLFLI 326
+A+ I L F I+ + T ++HF++FL+
Sbjct: 205 FSEIAVYLVICLAFFIILALYQFTETFHFIIFLL 238
gi|1407629 (U49052) cytochrome oxidase subunit I [Euglena gracilis]
>gi|1885316|emb|CAA69263.1| (Y07965) cytochrome-c
oxidase [Euglena gracilis]
Length = 495
Score = 33.6 bits (75), Expect = 2.9
Identities = 71/329 (21%), Positives = 128/329 (38%), Gaps = 78/329 (23%)
Query: 12 VGCCFLIFGLLNNLLYV--IILSAALDLVGANVSKGVVLLSNIVPSLACKLSASILHVHK 69
VG F+ + N + V I+L +L ++G ++ G++L NI ++ + +L+ H
Sbjct: 186 VGLTFMNINIYNFSIIVTSILLIGSLPILGVAIT-GLLLDRNINSTIYDVIGDPVLYQHL 244
Query: 70 FKFAKRIG-FCVFMSILGMQWIAWSSSVPSKMLG-VSLAAISSSFGEISF---------- 117
F F + + + + G+ + +S + + G + S G + +
Sbjct: 245 FWFFGHPEVYVIILPVFGLTSLILTSIIHKDIFGREGMMYCIISIGVVGYFVWAHHMFTV 304
Query: 118 -LHLSSR-YHSV-----SLPC----------WSSGTGLAGLFGASSYLVMTTWFNFSVRS 160
L + SR Y S+ S+P W+SG G G + S+ F F +
Sbjct: 305 GLDIDSRSYFSIATSIISIPTSVKMFSYINTWASGRGFRGNNSSWSFFSFLICFCFGGFT 364
Query: 161 TLIISS-FLPLFLLIMYFFVLPESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTF 219
L++SS L + L YF V GH F+ V SL TF
Sbjct: 365 GLLLSSGSLDIMLHDTYFVV-------------------------GH--FHTVLSLAATF 397
Query: 220 ------IFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFS-------SFRDF 266
F P + S+ + ++ + + +G A + +P AG S + D
Sbjct: 398 GLLIAHYFFLPIIFSYSIFESFSFYHTFLLLVG-ALLVFYPMHLAGLSGMARRVPEYADI 456
Query: 267 YPTYQTVYQIGVFLSRSSISFFTVPYLRT 295
+ + TV G FL + F T+ ++R+
Sbjct: 457 FIPFMTVGFHGTFL----LIFSTLTFIRS 481
sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CHROMOSOME I
>gi|2130277|pir||S62432 hypothetical protein SPAC13G6.3
- fission yeast (Schizosaccharomyces pombe)
>gi|1008988|emb|CAA91096.1| (Z54308) putative major
facilitator superfamily protein [Schizosaccharomyces
pombe]
Length = 758
Score = 33.6 bits (75), Expect = 2.9
Identities = 25/90 (27%), Positives = 46/90 (50%), Gaps = 9/90 (10%)
Query: 172 LLIMYFFVLPESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLLSHMF 231
+L + F +++ST +++N ++P ID V F V++L+ F+F + + + F
Sbjct: 17 ILFLLGFFPHKNDSTGKAMSNQFSPPAVID----QVVFVMVDALRADFVFSKSHNMP--F 70
Query: 232 PQFLVYFSEYTINIGV---APTLLFPPEKA 258
Q L+Y S + I +PT+ P KA
Sbjct: 71 TQSLLYNSTHGIGFSAFARSPTVTMPRLKA 100
prf||2107260F ORF [Acinetobacter calcoaceticus]
Length = 421
Score = 33.6 bits (75), Expect = 2.9
Identities = 29/122 (23%), Positives = 56/122 (45%), Gaps = 13/122 (10%)
Query: 71 KFAKRIGFCVFMSILGMQWIA--WSSSVPSKML-----GVSLAAISSSFGEISFLHLSSR 123
+F ++I + M + G +A +S+++ S ++ G+ L A + + + +R
Sbjct: 97 RFGRKIVLSMSMLVFGGFTLACAYSTNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPAR 156
Query: 124 YHSVSLPCWSSGTGLAGLFGA--SSYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVLP 181
S+ + C G L G SS+L+ F S ++ + PL L+++ F LP
Sbjct: 157 IRSLLVTCMFCGYNLGMAIGGFISSWLIPA----FGWHSLFLLGGWAPLILMLLVIFFLP 212
Query: 182 ES 183
ES
Sbjct: 213 ES 214
gi|2688484 (AE001158) conserved hypothetical integral membrane protein
[Borrelia burgdorferi]
Length = 283
Score = 32.8 bits (73), Expect = 5.0
Identities = 40/181 (22%), Positives = 70/181 (38%), Gaps = 20/181 (11%)
Query: 146 SYLVMTTWFNFSVRSTLIISSFLPLFLLIMYFFVLPESESTSPSINNNYTPIESIDLRAG 205
SYL++ +FNFS +T + F P ++ + I++ + I + L
Sbjct: 36 SYLLVRFYFNFS--ATDFLKFFAPKIFILTLIISIFTMCDYYKVIHDPFRNILYLSLPVS 93
Query: 206 HVSFNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSEYTINIGVAPTLLFPPEKAGFSSFRD 265
F N +K ++F P +L +Y+ I + + E F R
Sbjct: 94 TFEHYFFNLIK--YLFALPLIL------IFIYYLGVNIFLFLDNAFFLRGEGTPFLELRY 145
Query: 266 FYP-------TYQTVYQIGVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSS 318
FY + +++ I +F I+F T P+++ L I+L S LYL
Sbjct: 146 FYDFLFVRYFNFLSIFPIFMFFR---ITFKTHPFVKVLIFFLGTIVLLFFSTSFLYLGFK 202
Query: 319 Y 319
Y
Sbjct: 203 Y 203
gi|2316062 (AF002651) NADH dehydrogenase 6 [Limulus polyphemus]
Length = 153
Score = 32.8 bits (73), Expect = 5.0
Identities = 21/67 (31%), Positives = 35/67 (51%), Gaps = 7/67 (10%)
Query: 272 TVYQIGVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFLIFVEGL 331
T+Y +FL IS+ + + L +T ++ L T L L TS + + LFLI V G+
Sbjct: 9 TIYSSVLFL----ISYHPIMMIMNLILTTILVSLMTTL---LMKTSWFSYTLFLIMVGGM 61
Query: 332 IGGTVYV 338
+ +Y+
Sbjct: 62 LVVFIYI 68
gb|AAD40864.1|AF102710_1 (AF102710) cytochrome c oxidase subunit I [Rhygoplitis terminalis]
Length = 410
Score = 32.5 bits (72), Expect = 6.5
Identities = 23/105 (21%), Positives = 43/105 (40%), Gaps = 12/105 (11%)
Query: 219 FIFMQPYLLSHMFPQFL----VYFSEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVY 274
F+ + YL H + FL ++F ++ + +G P +S + D Y + +
Sbjct: 308 FMLNEKYLKIHFYLMFLGVNLIFFPQHFLGLGGMPRR--------YSDYPDMYLNWNLIS 359
Query: 275 QIGVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSY 319
G +S SI FF + + +FI+ + S +L Y
Sbjct: 360 SFGSLISLISILFFIFIIWESFLMKRFILFNKYLNSSIEWLQXXY 404
dbj|BAA16591| (D90899) iron(III) dicitrate transport system permease protein FecD
[Synechocystis sp.]
Length = 349
Score = 32.5 bits (72), Expect = 6.5
Identities = 29/91 (31%), Positives = 46/91 (49%), Gaps = 13/91 (14%)
Query: 33 AALDLVGANVSKGVVLLSNIVPSLACKLSASILHVHKFKFAKRIGFCVFMSILGMQWIAW 92
AA +++G N +V ++ IV L +S S+L V F G ++I + W
Sbjct: 107 AAPEIIGVNAGASLVAVTFIV--LLPGISPSLLPVAAFCG----GLTAAIAIYVLAWNQG 160
Query: 93 SSSVPSKMLGVSLAAISSS-------FGEIS 116
S+ V ++G+ LAA++SS FGEIS
Sbjct: 161 SAPVRLILVGIGLAALASSLTSLMVTFGEIS 191
gnl|NCBI_MITO|ATP6_10512 ATP synthase F0 subunit 6 >gi|3121793|sp|Q35538|ATP6_PETMA ATP
SYNTHASE A CHAIN (PROTEIN 6) >gi|1085190|pir||S55009
H+-transporting ATP synthase (EC 3.6.1.34) protein 6 -
sea lamprey mitochondrion (SGC1) >gi|515491 (U11880)
ATPase 6 [Petromyzon marinus]
Length = 237
Score = 32.5 bits (72), Expect = 6.5
Identities = 15/43 (34%), Positives = 25/43 (57%)
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFVLFL 325
S +F +P + IT ++LL TIL+ A+ + +Y F+L L
Sbjct: 176 SMTTFVMIPVISISIITSLLLLLLTILELAVAVIQAYVFILLL 218
emb|CAA80467.1| (Z22813) NisK [Lactococcus lactis]
Length = 447
Score = 32.5 bits (72), Expect = 6.5
Identities = 36/168 (21%), Positives = 68/168 (40%), Gaps = 25/168 (14%)
Query: 162 LIISSFLPLFLLIMYFFVLPE------SESTSPSINNNYTPIESIDLRAGHVSFNFVNSL 215
+II + L + LL+ F L + SE+ S++++ I I+ H ++++
Sbjct: 18 IIIGTCLLILLLLGLTFFLRQIGQISGSETIRLSLDSDNLTISDIERDMKHYPYDYIMFD 77
Query: 216 KQTFIFMQPYLLSHMFPQFLVYF-SEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVY 274
T + + + P F+ S + I G + TY +
Sbjct: 78 NDTSKILGGHYVKSDVPSFVASKQSSHNITEG------------------EITYTYSSNK 119
Query: 275 QIGVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFV 322
V L ++S+ FT LR+++ QF L F + + L + S YH +
Sbjct: 120 HFSVVLRQNSMPEFTNHTLRSISYNQFTYLFFFLGEIILIIFSVYHLI 167
dbj|BAA79236.1| (AP000059) 220aa long hypothetical protein [Aeropyrum pernix]
Length = 220
Score = 32.1 bits (71), Expect = 8.5
Identities = 27/114 (23%), Positives = 55/114 (47%), Gaps = 5/114 (4%)
Query: 115 ISFLHLSSRYHSVSLPCWSSGTGLAGLFGASSYL-VMTTWFNFSVRSTLIISSFLPLFLL 173
+ F H S + + S + G S+Y V W+ + R+ I ++ L
Sbjct: 15 VYFFHFGSSLFASLIIASISMIDIKGFLIWSAYARVYLPWYFLAGRACAISFAYSQLAFR 74
Query: 174 IMYFFVLPESESTSPSINNNYTPIESIDLRAGHVSFNFVNSLKQTFIFMQPYLL 227
MY+++L S S +P +++ I ++ ++ G +S +F+NS +F+F +L+
Sbjct: 75 -MYWYIL--SLSFTPCFRASFSRI-AVSIQGGLISLSFLNSSWYSFMFCMSFLM 124
gi|3168884 (AF068716) similar to E. coli thermoresistant gluconokinase
(GB:U18997) [Caenorhabditis elegans]
Length = 312
Score = 32.1 bits (71), Expect = 8.5
Identities = 27/90 (30%), Positives = 38/90 (42%), Gaps = 7/90 (7%)
Query: 112 FGEISFLHLSSRYHSVSLPCWSSGT-GLAGLFGASSYLVMTT-----WFNFSVRSTLIIS 165
F + +L SS + C S G A LFG Y++ T + V +I S
Sbjct: 6 FNNVHYLASSSSQPAAEQDCVSCKIIGTASLFGIGCYIIFATRPIGYYATRPVTRQIIRS 65
Query: 166 -SFLPLFLLIMYFFVLPESESTSPSINNNY 194
S +P + I FF LP ES P+ + Y
Sbjct: 66 LSAVPFYASIARFFYLPPFESIDPTKDTIY 95
gi|780431 (U18466) pM448R [African swine fever virus]
>gi|1097451|prf||2113434BM M448R gene [African swine
fever virus]
Length = 448
Score = 32.1 bits (71), Expect = 8.5
Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 7/39 (17%)
Query: 210 NFVNSLKQTFIFMQPYLLSH-------MFPQFLVYFSEY 241
N NS + FI +Q YL+ H +FPQ++ Y+++Y
Sbjct: 346 NISNSQRLEFIILQNYLMQHFRDHFIALFPQYISYYTKY 384
gnl|NCBI_MITO|ND6_10704 NADH dehydrogenase subunit 6 >gi|128814|sp|P18933|NU6M_DROME
NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6
>gi|85201|pir||S01189 NADH dehydrogenase (ubiquinone)
(EC 1.6.5.3) chain 6 - fruit fly (Drosophila
melanogaster) mitochondrion (SGC4) >gi|894080 (M37275)
ORF [Drosophila melanogaster] >gi|1166540 (U37541) NADH
dehydrogenase subunit 6 [Drosophila melanogaster]
Length = 174
Score = 32.1 bits (71), Expect = 8.5
Identities = 32/119 (26%), Positives = 52/119 (42%), Gaps = 20/119 (16%)
Query: 283 SSISFFTVPYLRTLAITQFIILLFTILQSALYLTSS-YHFVLFLIFVEGLIGGTVYVNVY 341
+SI F + + L +T I +F L + L S Y ++LFLIF+ G++ +YV
Sbjct: 13 TSIIFLNMIHPLALGLTLLIQTIFVCLLTGLMTKSFWYSYILFLIFLGGMLVLFIYVTSL 72
Query: 342 HSLQTTESSQR-----------ELAISTVGSSDSSGIFL--------ASLVSLFLEPSL 381
S + S + L +S + SS +FL ++ S F+E SL
Sbjct: 73 ASNEMFNLSMKLTLFSSLILIFMLILSFIMDKTSSSLFLMNNDMQSIINMNSYFMENSL 131
gnl|NCBI_MITO|COX1_10587 cytochrome c oxidase subunit I >gi|116993|sp|P05503|COX1_RAT
CYTOCHROME C OXIDASE POLYPEPTIDE I >gi|92960|pir||S04749
cytochrome-c oxidase (EC 1.9.3.1) chain I - rat
mitochondrion (SGC1) >gi|13480|emb|CAA32956| (X14848)
cytochrome-c oxidase I [Rattus norvegicus]
Length = 514
Score = 32.1 bits (71), Expect = 8.5
Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 26/96 (27%)
Query: 209 FNFVNSLKQTFIFMQPYLLSHMFPQFLVYFSEYTIN------------IGVAPTLLFPPE 256
F++V S+ F M ++ H FP FS YT+N +GV T FP
Sbjct: 377 FHYVLSMGAVFAIMAGFV--HWFP----LFSGYTLNDTWAKAHFAIMFVGVNMTF-FPQH 429
Query: 257 KAG-------FSSFRDFYPTYQTVYQIGVFLSRSSI 285
G +S + D Y T+ TV +G F+S +++
Sbjct: 430 FLGLAGMPRRYSDYPDAYTTWNTVSSMGSFISLTAV 465
sp|P42707|NISK_LACLA NISIN BIOSYNTHESIS SENSOR PROTEIN NISK >gi|628946|pir||S44133
histidine kinase - Lactococcus lactis
>gi|473023|emb|CAA54212| (X76884) histidine kinase
[Lactococcus lactis]
Length = 447
Score = 32.1 bits (71), Expect = 8.5
Identities = 36/168 (21%), Positives = 68/168 (40%), Gaps = 25/168 (14%)
Query: 162 LIISSFLPLFLLIMYFFVLPE------SESTSPSINNNYTPIESIDLRAGHVSFNFVNSL 215
+II + L + LL+ F L + SE+ S++++ I I+ H ++++
Sbjct: 18 IIIGTCLLILLLLGLTFFLRQIGQISGSETIRLSLDSDNLTISDIERDMKHYPYDYIIFD 77
Query: 216 KQTFIFMQPYLLSHMFPQFLVYF-SEYTINIGVAPTLLFPPEKAGFSSFRDFYPTYQTVY 274
T + + + P F+ S + I G + TY +
Sbjct: 78 NDTSKILGGHYVKSDVPSFVASKQSSHNITEG------------------EITYTYSSNK 119
Query: 275 QIGVFLSRSSISFFTVPYLRTLAITQFIILLFTILQSALYLTSSYHFV 322
V L ++S+ FT LR+++ QF L F + + L + S YH +
Sbjct: 120 HFSVVLRQNSMPEFTNHTLRSISYNQFTYLFFFLGEIILIIFSVYHLI 167
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Dec 29, 1999 2:49 PM
Number of letters in database: 135,346,764
Number of sequences in database: 440,253
Lambda K H
0.328 0.140 0.418
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97874547
Number of Sequences: 440253
Number of extensions: 3955876
Number of successful extensions: 18147
Number of sequences better than 10.0: 47
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 18028
Number of HSP's gapped (non-prelim): 71
length of query: 396
length of database: 135,346,764
effective HSP length: 53
effective length of query: 343
effective length of database: 112,013,355
effective search space: 38420580765
effective search space used: 38420580765
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.8 bits)
S2: 71 (32.1 bits)
